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Ethical issues of gene therapy
Ethics of genetic engineering
Ethical issues of gene therapy
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As medical technology and research advances, society’s once limited knowledge of the causes of diseases and disorders is growing. Along with this new information comes new methods of curing and at times, completely eliminating these diseases from the body. A new form of this is CRISPR-Cas 9 gene editing. According to the Your Genome article, “What is CRISPR-Cas9?,” CRISPR-Cas 9 is a “technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding, or altering sections of the DNA sequence” (“What is CRISPR-Cas 9?” para. 2). In other words, the enzyme, Cas-9, is able to go into a person’s DNA and change parts of it, completely changing a person, in either terms of physical attributes or diseases in …show more content…
The Time article, “How Gene Editing Could Ruin Human Evolution,” by Jim Kozubeck, acknowledges the construct in science that many doctors hold that men’s genes in life can be “broken.” Yet, this idea goes completely against Darwin’s idea of evolution, in which he “showed us that evolution does not progress toward an ideal model or a more perfect form, but instead is a work of tinkering toward adaptation in local niches” (Kozubeck para. 8). Kozebuck further emphasizes this point with the concept that “genetic variants that predispose us to risk or supposed weaknesses are precisely the same ones that turn out to have small fitness advantages (they make us better at numbers, more sensitive, alter concentration.” (Kozebuck para. 9). In other words, genes that cause disease can also come with attributes in a person that are seen as desirable. Therefore, eliminating these disease causing genes will also eliminate certain positive attributes, which can as a result, alter the evolution of humans negatively. The most prevalent drawback of CRISPR/Cas9 comes as the decline of
In the book, Crispin: The Cross of Lead, the protagonist Crispin faces many conflicts throughout the book in which he must conquer in order to find who he really is. These conflicts change Crispin as a character over the course of the book, as he overcomes them to find out his true self. One conflict for Crispin is person vs society where he becomes known as a wolf’s head and does not have any friends, or family. This is until he meets Bear who helps Crispin overcome this conflict. For example, John Aycliffe tries to find Crispin, but helps him get away. As the story develops Crispin saves Bear from John Aycliffe, showing their friendship.
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
Many people often ask, “Is it acceptable for human beings to manipulate human genes” (Moral and Ethical Issues in Gene Therapy). Most of the ethical issues centralize on the Christian understanding of a human being. They believe God made them the way they are and people should accept their fate.The Society, Religion and Technology Project have researched and found that countless people are curious if gene therapy is the right thing to do. They have a problem with exploiting the genes a person is born with due to the fact they consider it to be “playing God” (Moral and Ethical Issues in Gene Therapy). They are also concerned with the safety. On account of the unfamiliar and inexperienced technology. Gene therapy has only been around since 1990, so scientists are still trying to find the best possible way to help cure these diseases. Multiple scientists are cautious with whom they share their research. For the reason that if it were to get into in the wrong hands it could conceivably start a superhuman race. Author Paul Recer presumes using germline engineering to cure fatal diseases or even to generate designer babies that will be stronger, smarter, or more immune to infections (Gene Therapy Creates Super-Muscles). Scientists could enhance height, athleticism and even intelligence. The possibilities are endless. Germline engineering, however, would alter every cell in the body. People would no longer have to worry about the alarming and intimidating combinations of their parents’ genes. Genetic engineers are able to eliminate unnatural genes, change existing ones or even add a few extra. Like it or not, in a few short years scientists will have the power to control the evolution of
Have you ever felt safe with someone, even though by all appearance you should be terrified? In Crispin, written by Avi, “Asta’s son” faces a similar dilemma. Everyone agrees that Crispin remained with Bear after being captured, but some believe that Crispin should have stayed with Bear and some believe Crispin should not have stayed with Bear.
Crispin a story written by Avi has one main character, Crispin, who lives as a peasant in the small village of Stromford. He never meet his father and his mother died so the only thing he had left from them was a cross of lead. Crispin was declared a wolf’s head so he had no choice but to run away. While fleeing he found a man who called himself Bear. Bear made Crispin question all life and what he had been taught. Throughout Crispins journey he changed in ways that were not even thinkable for him at the beginning. He started as a boy who was timid and afraid who became a strong independent man.
One of the most controversial topics discussed in the world of medicine pertained to the topic of genetic engineering. Some doctors saw it as tool of world destruction, however many of them seeing it as a chance of potential cures and treatments. Charles Darwin first introduced this idea. In his first publication, The Origin of Species, he introduced the idea of survival of the fittest. He stated that evolutionary change was only possible due to the genetic variation between each generation, including the combination of different characteristics. In other words, he wrote that only those who had desirable characteristics, in terms of survival, would be able to pass down their genes. If two bred and possessed desirable characteristics, then the desirable characteristic would strengthen, modifying the genes. Darwin’s theories have been the base of many medical breakthroughs that contributed to genetic engineering. The idea soon influenced medicine, the idea of strengthening the healthy cells and isolating them from the unhealthy ones. The simple idea Darwin discovered had changed medicine as a whole. Today, doctors and scientists are able to manipulate genes in order to create new treatments and cures. Today, Darwin’s discovery changed and saved millions of lives around the world. Despite the fact that genetic engineering can have a negative impact on society, it was an important discovery due to the advancement in conventional medicine.
Gene therapy gives people who suffer from genetic diseases a chance to lead a normal life. Dangerous diseases, such as AIDS, SCID, Thalassemia and ADA can be cured successfully. In September 5, 2006, two people with advanced melanoma received Gene therapy and they got recovery soon. This is a breakthrough in cancer gene therapy. Gene therapy uses patients own cells to cure diseases, and, therefore, no rejection to their bodies. Furthermore, patients could get permanent cure from gene therapy without recurrence.
The diversity and the unity of life are equally meaningful and striking aspects of our Earth (Dobzhansky, 1973). Although an astounding 1.2 million species have already been identified, it is estimated that another 8.7 million are yet to be discovered and classified (Mora et al., 2011). By understanding what unifies us –our genes, our understanding of the organisms we share our planet with will continue to grow.
In the past 40 years, scientists have developed and applied genetic engineering to alter the genetic make-up of organisms by manipulating their DNA. Scientists can use restriction enzymes to slice up a piece of DNA from an organism with the characteristics they want and spliced (joint) to a DNA from another organism. DNA that contains pieces from different species is called recombinant DNA, and it now has different genetic material from its original. When this DNA inserted back into the organism, it changes the organism’s trait. This technique is known as gene-splicing (Farndon 19).
Gene therapy focuses on the replacement of defective genes with modified functioning genes. Many diseases are caused by a defective gene meaning the body is incapable of producing essential proteins or enzymes. In its simplest form, gene therapy aims to identify the defective gene and fix this gene with the replacement of a normal gene (Senn).
"The aim is to decrease the fear of a brave new world and to encourage people to be more proactive about their health. It [Gene therapy] will help humans become better physically and even mentally and extend human life. It is the future” (Hulbert). Dr. Hulbert, a genetic engineer, couldn’t be anymore right; more time, money, and research needs to be put into gene therapy and genetic engineering, since it can cure certain illness and diseases that are incurable with modern medicine, has fewer side-effects than conventional drugs or surgery, and allows humans to be stronger physically and mentally at birth. Gene therapy or genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population (NIH). It essentially means that we can change DNA to make an organism better. Genetic engineering is used with animals and plants every day; for example with genetic...
It was not that long ago that there was an age of no internet or computers. Life around the world has changed dramatically in the past thirty years. Technology has advanced at faster rate than ever before. We now know about many new things including humans including our DNA. It seems as though, the more we learn about the make up of our bodies, the more we are learning how to manipulate them. Do we want to let science take over our natural way of life? Russell Powell of the Journal of Medicine & Philosophy agrees that there is a common worry that humans could be harmed by genetic engineering of humans. The problem, Powell says, could potentially lead to the extinction of human life. By reducing human genetic diversity, we could end up with a biological monoculture that may increase our susceptibility to deadly diseases.
Human genetic engineering can provide humanity with the capability to construct “designer babies” as well as cure multiple hereditary diseases. This can be accomplished by changing a human’s genotype to produce a desired phenotype. The outcome could cure both birth defects and hereditary diseases such as cancer and AIDS. Human genetic engineering can also allow mankind to permanently remove a mutated gene through embryo screening as well as allow parents to choose the desired traits for their children. Negative outcomes of this technology may include the transmission of harmful diseases and the production of genetic mutations. The benefits of human genetic engineering outweigh the risks by providing mankind with cures to multiple deadly diseases.
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
In a recent study by Editas Medicine, they are working with CRISPR to prevent a blinding disorder called “leber congenital amarurosis” which is a rare inherited disease (Knapton, 2015). This disorder is due to a defect in a gene that encodes for a protein that is essential for vision, using CRISPR they are able to cut out the mutated areas. This is one example on how modifying DNA can be beneficial and why it should be accepted. Many inherited disorders like cystic fibrosis or Tay-Sachs. With parents having genetic screen tests they can provide a better future for their children and prevent them from a life with a