Butorphanol, A Mixed Opioid Receptor Agonist: A Case Study

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1. Introduction Butorphanol (butorphanol) is a mixed opioid receptor agonist, which mainly causes the excitement of κ receptors; it does not cause the excitement of the μ receptor, and its role on δ receptor activity is very low. Its analgesic effect on long-time pain, respiratory depression is strong and a low incidence of drug dependence [1,2]. At present, research on butorphanol is mostly conducted in intraspinal analgesic medication and the intravenous analgesia [3]. The role of butorphanol nasal spray as postoperative analgesia is rarely reported in the literature. This randomized, double-blind experiment was designed to observe the law for Historical laparoscopic surgery after the analgesic effect and adverse reactions. 2. Data and Methods 2.1 General Information: During 2012.11 to 2013.03 in Alwehda Teaching hospital, Dhamar University. Yemen 60 cases of Historical laparoscopic surgery patients, with the age of 18 to 65-year-old, a weight of 40 ~ 90 Kg, and ASA (American Society of Anesthesiologists) I~II grade were taken for our study who had preoperative no history of hypertension, liver, kidney function abnormalities. 60 patients were randomly divided …show more content…

Butorphanol has the role of opioid receptors so that a small number of patients can have their own respiratory depression, peripheral vascular resistance increased, decreased myocardial contractility and other side effects [8]. Experimental observation of the patients was all healthy adult male and female, with the exclusion of cardiovascular and respiratory diseases from patients. So the breathing and circulation of a patient of butorphanol group were less affected. For the patients suffering from cardiovascular diseases respiratory dysfunction, the use of butorphanol should be

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