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Conclussion on gene therapy with ethical issues
Short essay on the advantages of gene therapy to humans and to society
Conclussion on gene therapy with ethical issues
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Gene therapy has been around for quite some time, where the earliest trial had occurred to a four-year-old girl back in 1990 at the NIH Clinical Center. She had possessed ADA deficiency a disease that target the body's immune system, leaving it defenseless from foreign invaders. White blood cells were taken out of her body and the genes that make adenosine deaminase were inserted into them and then reinserted back into her body. Gene therapy spans farther back to 1985 when it was first introduced into modern medicine by Drs. W. French Anderson and Michael Blaese. The process behind Gene Therapy is an experimental technique that uses genes in order to treat or prevent diseases. It is designed to introduce genetic material into cells to compensate for abnormal genes, a new gene is injected into an adenovirus vector, which is used to introduce the modified DNA into a human cell. If the treatment is successful, the new gene will make a functional protein. A …show more content…
Before it can be perfected, several studies have been shown that there have been serious health risks, such as toxicity, inflammation and cancer, since the technique is relatively new it, medical researchers and regulatory agencies are working to ensure the that gene therapy is a safe procedure. The ethical background on gene therapy is harshly surrounded around on things such as high cost and affordability depending on the severity of the disease and if only the wealthy will be able to afford the treatment, another is who decides which traits are normal and which constitute a disability or disorder. The biggest controversy is if people should be allowed to use gene therapy to enhance basic human traits such as height, intelligence, or athletic
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
Gene therapy is reinserting certain genes that helps deal with genetic diseases. There are three basic forms of this gene therapy. The first is Gene Inactivation Therapy in which the transferred gene neutralizes the proteins and evens out the amount or rids of the defective proteins. Another type is Gene Augmentation Therapy where the original form of the gene or the normal form of the gene is inserted into one of the cell’s chromosomes. This procedure is used normally when a gene with little activity or a deleted gene is the cause for the genetic disease. The third type of gene therapy is Gene Replacement Therapy. This form is used when the genetic disease involved specific genes that are necessary for proper functioning. The normal gene being put in place of the mutant gene accomplishes this form of gene therapy.
Many people often ask, “Is it acceptable for human beings to manipulate human genes” (Moral and Ethical Issues in Gene Therapy). Most of the ethical issues centralize on the Christian understanding of a human being. They believe God made them the way they are and people should accept their fate.The Society, Religion and Technology Project have researched and found that countless people are curious if gene therapy is the right thing to do. They have a problem with exploiting the genes a person is born with due to the fact they consider it to be “playing God” (Moral and Ethical Issues in Gene Therapy). They are also concerned with the safety. On account of the unfamiliar and inexperienced technology. Gene therapy has only been around since 1990, so scientists are still trying to find the best possible way to help cure these diseases. Multiple scientists are cautious with whom they share their research. For the reason that if it were to get into in the wrong hands it could conceivably start a superhuman race. Author Paul Recer presumes using germline engineering to cure fatal diseases or even to generate designer babies that will be stronger, smarter, or more immune to infections (Gene Therapy Creates Super-Muscles). Scientists could enhance height, athleticism and even intelligence. The possibilities are endless. Germline engineering, however, would alter every cell in the body. People would no longer have to worry about the alarming and intimidating combinations of their parents’ genes. Genetic engineers are able to eliminate unnatural genes, change existing ones or even add a few extra. Like it or not, in a few short years scientists will have the power to control the evolution of
Gene therapy works in three ways; it works to replace a missing or defective gene with a normal one, replace a faulty gene so that it will function properly and it works to activate and deactivate a gene, allowing it to “switch” on and off. Gene therapy is done by the deliverance of a gene to a cell via a carrier, or vector, such as a virus. Scientists lean more towards using a virus because they can seek out particular cells and transfer pieces of deoxyribonucleic acid into them. Scientists also take advantage by deactivating their harmful characterizes and modifying them to carry particular gene into designated cells. After gene therapy is done, the genes can then stimulate the production needed for standard functioning, allowing that gene to return to its previous normal state. Therefore, if a patient were to be in the beginning stages of cancer, gene therapy would seek out the cancerous gene and replace it with a healthy one and minimizes the disease from
Gene therapy gives people who suffer from genetic diseases a chance to lead a normal life. Dangerous diseases, such as AIDS, SCID, Thalassemia and ADA can be cured successfully. In September 5, 2006, two people with advanced melanoma received Gene therapy and they got recovery soon. This is a breakthrough in cancer gene therapy. Gene therapy uses patients own cells to cure diseases, and, therefore, no rejection to their bodies. Furthermore, patients could get permanent cure from gene therapy without recurrence.
Gene therapy is a provisional technique that is the insertion of normal genes into the cells where there is a missing or miscoded gene to fix a genetic disorder. In the 1960s and early 1970s,
This paper goes over genetic engineering and how it is used today in the medical field as two types on humans, disabled genetic engineering and trait genetic engineering. This two types of genetic engineering are still debatable since they have to surpass many obstacles and laws. The sources gave statements from professionals and experts on genetic engineering, biomedical science, biomedical engineering, and human anatomy and physiology. The individuals gave their inputs on how they view genetic engineering on human beings.
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Human Genetic Engineering: Designing the Future As the rate of advancements in technology and science continue to grow, ideas that were once viewed as science fiction are now becoming reality. As we collectively advance as a society, ethical dilemmas arise pertaining to scientific advancement, specifically concerning the controversial topic of genetic engineering in humans.
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
In an article titled “The Ethical Implications of Gene Therapy” the group of advisers on Ethical Implications of Biotechnology of the European commission states issues and rules that should be abided by, along with beliefs on the direction of biotechnology. At its present stage, biotechnology focuses on serious diseases which are incurable at the moment, however through this research treatment for these diseases could be found. The group of advisers feel that there should be levels at which research should focus on, instead of jumping into it all at once. Basic research should be carried out prior to clinical trials, and then move on to biotechnology. This can be done by supporting research actions, organizing training and exchange programs or any other appropriate means. Gene therapy protocols require that ethical evaluation consists of processes assuring quality, transparency and efficiency without delays of treatment to the patients who need it. This is crucial because an inefficient, poor quality treatment could cost someone their life. The group also feels that gene therapy research should be restricted to serious diseases for which there is not a current treatment. Expanding research to other things could be done if a medical evaluation calls for it. Equal access should be assured to all researchers within the European Union, thus sharing information and helping to improve orphan drugs. This could also save time and money. In order to insure the public of what is going on, conclusions of evaluations should regularly be published to encourage public debate. The public is not usually informed much about genetic therapy and many people have the wrong idea about it. Should reports be published more often, there will be less public confusion and ridicule.
patient. Any effects of the therapy will be restricted to the patient and will not be
Scientists and the general population favor genetic engineering because of the effects it has for the future generation; the advanced technology has helped our society to freely perform any improvements. Genetic engineering is currently an effective yet dangerous way to make this statement tangible. Though it may sound easy and harmless to change one’s genetic code, the conflicts do not only involve the scientific possibilities but also the human morals and ethics. When the scientists first used mice to practice this experiment, they “improved learning and memory” but showed an “increased sensitivity to pain.” The experiment has proven that while the result are favorable, there is a low percentage of success rate. Therefore, scientists have concluded that the resources they currently own will not allow an approval from the society to continually code new genes. While coding a new set of genes for people may be a benefitting idea, some people oppose this idea.
Position Paper: Gene Therapy in Humans. Advancements in science and medicine are usually accompanied by a myriad of ethical and moral implications. The fairly recent advancement in genetics, called gene therapy, is no exception to the baggage of polarizing views that come with new technology. Gene therapy is an extremely hot topic in both the scientific world and everyday life. New technology, discoveries, and breakthroughs are rapidly occurring in the field every day.
What are the risks and what are the possible benefits? Currently, gene therapy is one of the only ways to change the genetic makeup of an animal or human. Also, the chance of gene therapy being successful in animals is fifty percent, while in humans it is five percent. Human Genetics Alert believes “Once we begin to consciously design ourselves, we will have entered a completely new era of human history, in which human subjects, rather than being accepted as they are, will become just another kind of object, shaped according to parental whims and market forces”. HGA provides background information on the currently available resources used in Genetic Engineering.