Amphetamine Sulphate Synthesis Lab Report

Amphetamine – Amphetamine sulphate synthesis

5g P2NP

50ml Isopropanol

7, 5-8,5g of Aluminum foil (better to use thick foil)

50ml 98% acetic acid (can also use 70%, than don’t need water)

50g NaOH

1ml H2SO4

You will make mix with acetic acid and water. Water is need because you use 98% of acetic. Pour (50ml GAA + 25mldH2O) in to 250ml Erlenmeyer flask.

Prepare solution of 5g P2NP and IPA. Dissolve 5g in to 50ml of warm IPA. Let to cool.

While IPA solutions are cooling, you need to make aluminum amalgam. Cut the squares into 1x1 pieces. Put aluminum squares into 200ml dH2O, add 50mg of Hg (no3) or other Hg salts and stir. After 5-10 minutes you will see grey remains in the jar. That means the amalgamation has started and you need to wait 10 minutes. Wash aluminum with water 3 times and wash out all remains and Hg (no3). Because Hg salts are very dangerous.

You are ready to start the reaction.

Add aluminum amalgam in to acetic acid with water and mix. Wait for about 3-5 minutes, while solution will turn grey. Then add P2NP solution and wait 5-10 minutes while stormy reaction starts. Let the flask to stay for about 20-25 minutes.

After storm reaction is over, put the flask on the hotplate and make reflux for 1 hour. At this moment SWIM doesn’t have a hotplate, so use boiling water bath. When the reflux is over, let it cool to room temperature. You will have a red/yellow solution.

While the solution is cooling, you need NaOH. Add 50g NaOH into the jar and pour 50ml dH2O. The solution will be very hot so cool it by putting it in the freezer. When the two solutions are cooled, start to pour NaOH solution. Pour in small amounts because all of the mixes in the Erlenmeyer flask will start to heat. Add it slowly and stir after addition. You need to do this while you see 2 layers; the ph will be 10-12. When the NaOH is added, wait while all solution cools because you need to pick the top layer

(red/yellow).
Now you need to convert freebase to amphetamine sulphate. You will do this by sulfur acid and isopropanol (Solution H2SO4 + IPA (1ml +5ml). Drop by drop pour the acid solution to the freebase and stir a lot. You will see how amphetamine sulphate appears. Add acid solution while the ph will be (ph 7). Filtrate all amphetamine sulphate and let it dry in a warm place.