Acromegaly is a pituitary gland disorder that is an unusual and rare disease that comes from the hypersecretion of growth hormone during adulthood. It is rare in that acromegaly occurs in about 5 cases per million per year (Lugo 2011). Acromegaly if often labeled as a prolonged metabolic condition that is characterized by steady enlargement or elongation of facial bones and extremities (Thibodeau, 2013). This paper will explain the disease and how it affects the body, how one who has the disease might act and how to diagnose the disorder, and how to treat the disorder and ways for prevention of acromegaly. Acromegaly causes a number of physical changes over time. Since growth hormone is accountable for organ, bone, and muscle growth, excess growth hormone leads to an abnormal growth of these tissues. Individuals with acromegaly may have swelling in the hands and feet and develop a severe facial appearance as the jawbone projects, the tongue enlarges, and the chest rounds (Reid, 2009). The heart grows larger, which damages its role, and other tissue growth tightens the nerv...
Complex linkages are system of activities, business organization, resources, and information involved in transferring services and product from supplier of the product to customers. In complex linkage, the products and services from a single company interact in several ways. The complex linkage needed for a competitive business environment should focus on business management, connection with other countries, development of new markets, and technology.
ACHONDROPLASIA is known as being undersized, or less than 50in. in height. Having short limbs, a normal sized trunk, large head with a depressed nasal bridge and small face. This is a result of a disease in the thyroid gland. It can also be caused by Down syndrome or absorption, a cartilaginous tissue during the fetal stage. Hypochondroplasia, a mild form of dwarfism. Spinal tuberculosis and the deficiency of the pituitary gland secretions. Treatment with thyroxin or thyroid extract early in childhood results in normal growth and development. Somatrophin, also known as the human growth hormone is secreted by the anterior pituitary. Respiratory problems start to occur in infants. Symptoms of problems include snoring and sleeping with neck in a hyperextended condition. The limbs have rhizometic shortening. The legs are straight in infantry but when a child. He begins walking they develop a knock-knee position. When the child continues to walk legs begin to have a bowed-leg look. Occasionally, these curvatures are fixed. As the child continues to walk the kyphosis disappears and the back assumes a lordotic posture. If a delay in child’s walking occurs, the spine should be monitored closely for signs of gibbous formation. In infancy, hypercephalus can occur. Infants head circumference should be monitored close . Monthly checks of head circumference must be monitored. Radiologic studies are indicated if head circumference raises to disproportionately, or if symptoms of hydrocephalus. Child’s pediatrician should have a copy of head circumference curves for children with achondroplasia. Radiologic procedures for dwarfism include head ultrasound, C-T scan, or MRI of the head. If intervention is necessary, a ventriculoperitoneal shunt is placed relieving the pressure. Infants should also be monitored for foramen magnum compression. It is the opening at the base of the skull in which the brain stem and cervical spinal cord exit. When you have achondroplasia the foramen magnum is compressing the brain stem and spinal cord. Symptoms of narrowing include apnea the cessation of breathing and cervical myleopathy. C-T scans and MRI scans are done to examine the size of the infectious foramen magnum. A neurosurgical procedure called a foramen magnum decompression is executed to alarge foramen and alleviate further symptoms. Adolescents are at risk of getting lumbosacral spinal stenosis. The lumber spinal cord or nerve roots become compressed producing nerosurgical symptoms. Initial symptoms including weakness, tingling, and pain of the legs. Pain usually alleviated by assuming a squatting position.
ACH, is an interesting disease, one that after many years of research still remains a partial mystery. The fact that a single nucleotide on one chromosome can so greatly affect an individual is astounding, especially coupled with the fact that this mutation is so homogenious in genotype and phenotype. With more skeletal dysplasias being connected to FGFR3, research has increased to fully determine and define the pathways involved with this gene. Determining the reason for such a high mutation frequency and the link to paternal age are also being looked into. Once there is more understanding of how this mutation affects the body, treatments and possibly cures can be found for these individuals.
Algernon is a super genius. He can complete difficult tests and also happens to be a mouse. Algernon’s character develops in three stages. His peak in intelligence after an experimental operation defines him in the beginning. Later, Algernon is frustrated when this new intelligence begins to wear off. His brain continues to regress to a level even lower than it was prior to the operation, ultimately ending in his death. These stages are not only important for the character development of Algernon but for Charlie’s too.
Congenital Adrenal Hyperplasia (CAH) is an inherited condition that affects hormone production in the adrenal gland. The individual lacks enzymes to make cortisol, and hormones are instead are shifted away to make other hormones, specifically androgens. This results in the deficiency of cortisol and the abundance of testosterone.
Ivy was born with achondroplasia, the most common form of dwarfism. It is caused by the presence of two mutant alleles in the fibroblast growth factor receptor-3 (FGFR3). It is a substitution, to be precise, at nucleotide number 1138 in the DNA. This substitution on the DNA level results in a minute change on the protein level. This change in the protein impairs the function of the FGFR3 receptor. It is not currently known how this change produces the features of achondroplasia, but scientists are working on it.
The historian Richard White states the Columbia River, located in the states of Washington and Oregon in the Northwest portion of the United States, as an Organic Machine made by arguments that the habitat established by the environment dictates the survival of mankind. It was previously assumed that mankind dictates the laws of its existence and that the environment is simply a small obstacle that can be overcome. Richard White proves former beliefs about the relationship between mankind and its environment or habitat untrue through the book The Organic Machine by showing the reader why the Columbia River is a perfect example of an organic machine, how organic machines affect lives and different civilizations, and how the alterations that mankind makes can effect the river as a whole.
Achondroplasia is a genetic disorder in which there is a growth hormone deficiency, or there is a genetic mutation in either the father’s sperm or mother’s egg. Mayo Clinic, March 20, 2014. Achondroplasia was the first discovered in ancient Egyptian records. People with achondroplasia are considered people with supernatural powers. Many people call dwarfs midgets, but to them, it is very disrespectful because midget literally means little person.
The Computron, Inc. is facing problems regarding pricing the bid for Computron 1000X, future functioning of Frankfurt plant, impact on production due to current market breakdown.
HGH (Human Growth Hormones), Steroids and other PED’s (Performance Enhancing Drugs) have been linked to the game of baseball now since the 1990’s. Some wonder if these such drugs in fact hurt the human body. Yes they do. The drugs these athletes are putting into their bodies are often foreign things. However HGH is a substance that is produced in the pituitary gland. The substance regulates somatic bodily and skeletal growth says Robert E. Murphy of the Huffington Post (Par. 4). Murphy also goes on to talk about how HGH is most often found in young children and adolescence but it continues to sustain adult tissues and organs. So by putting or replacing what the young adults are starting to lack will in fact will strengthen and athletically enhance the athlete or person that takes this HGH. In 2008 a Stanford University study reported growth-hormone injections increased muscle bulk and not strength, and in fact might be a cause of muscle fatigue and joint-pain. Murphy talks about how The Mayo Clinic website incorporates such ...
particularly if the treatment is started at a young age (Ross par. 15). The growth hormone treatment can eventually increase the girl’s final adult height by several inches.
The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes its way to the bloodstream until it reaches the thyroid where it is then signaled to activate T3 and T4 production [1]. This mechanism is controlled by a negative feedback loop meaning that when there is a sufficient amount of thyroid hormones in the blood stream, this will signal back to stop production of thyroid stimulating hormones. Complications occur when the thyroid hormones keep increasing even though there is already a sufficient amount of T3 and T4 in the blood stream. This process of over expression of thryroid hormones is known as hyperthyroidism. Hyperthyroidism is a general term that includes any disease that has a consequence of an overabundance of thyroid hormones. Hyperthyroidism is a general term but there are many variant diseases that are in the hyperthyroidism category. These diseases include diffuse toxic goiter, Basedow’s disease, thyrotoxicosis, Parry’s and Graves’ disease.
Among these disorders are hypothyroidism and hyperthyroidism. Hypothyroidism is a disorder in which one is diagnosed for having and underactive thyroid. The probability for women over the age of sixty to develop an underactive thyroid is higher than those of other individuals. If left untreated it can potentially lead to obesity, joint pain, heart disease, and other health complications. On the contrary, hyperthyroidism is a disorder in which a person is diagnosed for having an overactive thyroid. This can cause nervousness and anxiety, hyperactivity, unexplained weight loss, and swelling of the thyroid gland which causes a noticeable lump to form on throat (known as a
Arthrogryposis is a disorder in which a child is born with joint contractures; this means some of their joints may be stuck in one position (curved or crooked). Children born with this disorder may have thin, weak, stiff, or missing muscles around these joints. The most common cause of arthrogryposis is fetal akinesia which is where the baby doesn’t move around a lot in the womb during development. Extra tissue can form in the joints making movement more difficult for the child to move. The reasons that fetal akinesia can take place may be because the womb was abnormally shaped so there wasn’t enough room for the baby to move around, amniotic fluid may have leaked out of the womb, or the baby’s parts did not form normally such as joints, bones, and muscles. They have also found that in approximately one third of the children who have this disorder have been determined to be a genetic cause.
There are many different types of dwarfism that researchers have confirmed today, but there still are many genes for dwarfism that remain unidentified.The most common of these known causes is achondroplasia, a bone growth disorder.The Little People Online website states that most dwarfs who suffer from achondroplasia are born to “average-size” parents, and that their birth rate is somewhere between onein26,000-40,000www.lpaonline.org).The main characteristics of this form of dwarfism are normal trunk size with short appendages, irregularly large heads wi...