Sex Determination and Differentiation

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Sex determination is decided by the 23rd pair of chromosomes commonly known as the sex chromosomes. Males have XY as their 23rd pair and females have XX. A female gamete, the ovum, can only receive only the X chromosome and the male gamete, the spermatozoon can receive either the X or the Y chromosome when meiosis occurs. Therefore the male sperm is responsible for the sex determination of the baby. Example: Figure 1: a Punnet square showing that there is an equal opportunity for a foetus to develop into either a male or female. It also shows how the male gamete determines the foetus sex by combining the X chromosome with either an X or Y chromosome. Once the sperm fuses with the ovum both chromosomes will pair up and begin the first stages of cell division. It won't be until the 6th week of gestation that we can start to determine the foetus' sex. This is because the testes determining factor (TDF), a hypothetical substance that does as its name says it does. It will determine whether the foetus develops testes or not. The reason it isn't called ovaries determining factor is because the Y chromosome controls the development of the testes. On the Y chromosome there is a region called sex-determining region of the Y, SRY, this is the region that has the genes to control the growth of the testes. If the Y chromosome is not present then there is no SRY therefore the male gonadal tissue (see later) will not develop and the female gonadal tissue will take advantage and develop into the female reproductive system. Development of the Male Internal Reproductive System Once the SRY gene is activated, it will cause the secretion of Mullerian-inhibiting substance (MIS) by the Sertoli cells within the seventh ... ... middle of paper ... ...e distal ends of the Mullerian ducts will form the oviducts, uterus and vagina. The opposite ends will form the fallopian tubes. The genital tubercle will from the clitoris, urethral folds remain open as the labia minora and the labioscrotal swellings become the labia majora. Summary The SRY gene is the initiator of sex determination and unless this gene is present all developing foetuses will be female. This is due to the high level of female hormones in the blood from the mother. It isn't until the Y chromosome is present with the SRY gene on it to degenerate the female tracts (Mullerian) and promote male tracts (Wolffian) by the release of anti-Mullerian substance and the stimulation of the Sertoli cells to secrete testosterone which leads to the release of hCG to stimulate the release of DHT to promote growth further and overcome the maternal hormones.

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