Tissue Engineering

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Recommended: About Tissue engineering

Tissue engineering is a field which involves biology, medicine, and engineering. It aims at restoring, maintaining and enhancing tissue and organ function by implanting natural, synthetic or semi-synthetic tissue and bioartificial organs that are fully functional from the beginning, or that grow into the required functionality (Nature Publishing Group., 2014). It is emerging as a potential alternative or complimentary solution for organ failure.

Basic Tissue Engineering Principles (Castells-Sala, et al., 2013).

A real-life example of its application in the human body is in wound repair. The main focus of tissue engineering in this application is in artificial skin to treat burns but it can also be used in various other dermal diseases. An example of this is the Advanced Tissue Sciences Dermagraft, which is a 3 dimensional human neonatal dermal fibroblast culture that has been grown on a biodegradable scaffold and has been cryopreserved (Nature Publishing Group., 2014). The main function of a scaffold is to direct cell behaviour such as migration, proliferation, differentiation and maintenance of phenotype (Amoabediny, Salehi-Nik, & Heli, 2011). The use of this Dermagraft is in the treatment of foot ulcers that have developed as a side effect of long – term diabetes. According to clinical trials, significant healing occurred with this material especially when the Dermagraft cells were alive and fully functional.

The manner in which the Dermagraft works is that it is placed on the ulcer and the mesh material gradually seeps into the skin where the human cells grow into place and replace the damaged skin. The living cells present in the Dermagraft produce many of the same proteins and growth factors found in healthy skin whi...

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...ssue Engineering/Regenerative Medicine. Retrieved April 5, 2014, from Tissue Engineering Pages: http://www.tissue-engineering.net/index.php?seite=whatiste

WebMD. (2012, December 14). WebMD. Retrieved April 27, 2014, from Central Venous Catheters: http://www.webmd.com/pain-management/tc/central-venous-catheters-topic-overview

Wendt, D., Timmins, N., Malda, J., Janssen, F., Ratcliffe, A., Vunjak-Novakovic, G., et al. (2008). Chapter 16: Bioreactors for tissue engineering. In C. van Blitterswijk, P. Thomsen, A. Lindahl, J. Hubbel, D. F. Williams, R. Cancedda, et al., Tissue Engineering (pp. 484-488). Elsevier Inc.

Yannas, I. V. (2000, August 15). pnas.org. Retrieved April 27, 2014, from PNAS: www.pnas.org

Zielinski, B., & Lysaght, M. (2007). Chapter 28: Immunoisolation. In R. Lanza, R. Langer, & J. Vacanti, Principles of Tissue Engineering (p. 399). Elsevier Inc.

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