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Case study of parkinson's disease
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The goal of this paper is to compare the utility of adult, embryonic and induced pluripotent stem cells (iPSCs) to treat Parkinson’s disease. As such several things will be assessed, dosage of stemcells, improvement in motor function, in combination with the presence of α-synuclein proteins and cell survival. To give a short overview of the steps that will be taken to complete the study. Obtaining stem cells, whether adult, embryonic or induced, shall be done using healthy mouse models and after ethical approval has been gained. The process to derive them will be detailed below, however they are also purchasable commercially with the benefit of being well studied and accompanied by a detailed analysis of properties, however with a higher purchasing costs. All steps should be done using sterile techniques to avoid contamination, both to object and self. All (disposable) materials should be sterilized and (where possible) only for 1 time use, due to the sensitivity stem cells have to detergents. After verifying they are bonafide stem cells the next phase should be ready to commence. Rats will be used as a disease model. All will be healthy, adult and a baseline PET scan and performance on a rotarod will be done. All but 1 set will then be subjected to a neurotoxin to mimic the diseased Parkinson state. Another PET scan and rotarod test will be done on all groups. The groups affected by the neurotoxin will then be subdivided into those receiving the different types of stem cells, one subgroup will receive no treatment and one group will receive medium (no cells). Next to this 2 different dosages will occur. Another PET scan and rotarod will be done to determine if any improvement occurs. Rats will then be sacrificed to determi... ... middle of paper ... ...ter a 6-OHDA lesion of the substantia nigra in a single hemisphere and if the injected cells would become infected by α-synuclein proteins. References: Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA. 2002;99:2344–2349. Lerou, P.H. et al. Derivation and maintenance of human embryonic stem cells from poor-quality in vitro fertilization embryos. Nat. Protoc. 3, 923– 933 (2008). Mead R. 1988. The design of experiments. Cambridge, New York: Cambridge University Press. 620 p. Takahashi, K., Okita, K., Nakagawa, M. & Yamanaka, S. Induction of pluripotent stem cells from fibroblast cultures. Nat. Protoc. 2, 3081–3089 (2007).
The Controversy over Stem Cells and Parkinson's Disease Without any thought, without even noticing it happens, when one has an itch, they scratch it. The arm moves up to the face, the fingers reach down and move across the skin. This series of actions, which many of us do everyday is something individuals with Parkinson's disease struggle with every moment of their lives. Simple movements are replaced by frozen limbs that they or their nervous system can not move. Described by many as a type
Thesis: Stem Cell research in Parkinson’s disease has been proven difficult due to political and scientific setbacks, but is a promising and effective treatment with those suffering from the disease. This disease has impacted my family in many ways. My father’s father passed away from pneumonia secondary to Parkinson’s Disease in May of 2017, and my mother’s mother is currently battling the disease now. Both have displayed different symptoms throughout their illness, which just shows you how tricky
Stem cells have several potential applications. Stem cells can be used to study development by helping us to understand how a complex organism develops from a fertilized egg. Some of the serious medical conditions such as cancer and birth defects which are lead by abnormal cell division and differentiation will have new therapy dealing with stem cell research. Stem cells have the ability to replace damaged cells and treat disease of extensive burns, leukemia (a cancer of blood forming tissues) and
Stem cell research is known to be a major taboo practice throughout the United States. In July 2015 Planned Parenthood received a substantial amount of backlash when a representative was video recorded making an attempt to sell aborted fetuses for research purposes. This video brought stem cell research into light and received a lot of controversy amongst the United States. Based on religious values, many individuals in the United States believe that stem cell research is unethical and morally wrong
"Stem cell research is the key to developing cures for degenerative conditions like Parkinson's and motor neuron disease from which I and many others suffer." -- Stephen Hawking As college students, it is important that we know and care about the issue of stem cell research. Stem cell research is currently legal in most countries. The United States, normally a leader in new frontiers, is one of the last to explore this territory. As it is slowly being pushed forward, we are going to have to know
The neurodegenerative diseases include a wide range of acute and chronic conditions in which there is a loss of neurons or and glial cells in the brain and spinal cord. For example, there is a loss of dopamine neurons in Parkinson’s disease, and motor neurons in Amyotrophic Lateral Sclerosis.1 The study we will be conducted is intended to research on how gender affect transfer of mitochondrial, and or exosomes as a stem cell repair mechanism in neurodegenerative diseases. Primarily, Many studies
Embryonic stem cell research is wrong. When using embryos in research, the embryo is manipulated to be anything scientists need it to be. But, scientists dispute the fact that the parts of the embryo they use could also grow into a fetus. When harvesting the stem cells of an embryo, the destruction of the blastocysts, “the blastula of the mammalian embryo, consisting of an inner cell mass, a cavity, and an outer layer, the trophoblast” (Dictionary.com), must occur. This kills the embryo because taking
tem cell therapy is a type of cell therapy wherein cells are introduced into the damaged tissue so as to treat the disorder or the injury. There are a number of medical researchers who believes that the stem cell therapy has the potential to change the treatment of human diseases and reduce the suffering people face when they have a disease. They believe that there are a lot of potential to replace the damaged and diseased tissues in the body without getting the risk of rejections. The stem cells
Daniel Long My Favorite Cell: The Stem Cell Stem cells are amazing cells that all humans possess throughout their bodies. In today’s world of science, stem cells have become important factors in scientific research. Research with stem cells has been increasing exponentially over the last decade. Around the world, stem cells have been studied to help treat various health problems. The extent to what stem cell research can do is very wide reaching. The existence of stem cells was theorized by Alexander
Embryonic Stem Cells Save Lives Special cells that are taken from human embryos, called embryonic stem cells (ES cells), actually possess the power to save your life. These cells can serve many medical purposes and have the ability to benefit people in infinite ways. The importance of embryonic stem cells rests in their lack of specialization. These basic cells are present in the earliest stages of developing embryos and are able to develop into virtually any type of cell and tissue in the
Parkinson’s Disease Parkinson’s Disease (PD), known for its degenerative abilities and debilitating affects, is an illness that affects approximately 1 million Americans. The cause of this disease has not been pinpointed, although strides have been made towards a cure. As our elderly population increases, so does our overwhelming need to find a suitable cure that may one day eliminate this disease. Concepts of PD After watching the video: My father, My Brother, and Me, viewable at www.pbs
As the human race is moving towards advancement the number of diseases and disorders are also on increase. To fight against these problems many new health care field have emerged since the past half-decade. Most promising of those fields is the Regenerative medicine. Regenerative medicine is a multidisciplinary field concerned with creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, or congenital defects (US National Institute of Health). It
Every year countless people are diagnosed with cell based diseases, 7.6 million a year alone receive the petrifying news that they have cancer. But what if we could eliminate the idea that a cancerous diagnosis is the equivalent of a death sentence? The use of embryonic stem cells could, for the first time, make diseases like cancer or parkinson a non-issue. This is why the use of embryonic stem cells should not be viewed as unethical but rather a huge step towards unthinkable medical breakthroughs
Embryonic Stem Cell Research! Danielle Case Baker College Embryonic Stem Cell Research! “In November of 1998, scientists reported that they had successfully isolated and cultured human embryonic stem cells a feature which had eluded researchers for almost two decades.”(The center for bioethics & human dignity, n.d.). This announcement kicked off an intense and unrelenting debate between those who approve of embryonic stem cell research and those who are opposed to it. “Some of the most
BIO.152 Buse Gizem Danış 2011207120 Embryonic Stem Cells vs Induced Pluripotent Stem Cells: Why do they Generate so Much Excitement Stem cells have an ability to change into other types of cells in body or in laboratory during early life and growth. Since stem cells can generate into a range of cell types such as bone, muscle, skin, cartilage and other specialized types of cells, they have the potential to treat many diseases like Parkinson's, Alzheimer's, diabetes and cancer. It is expected that