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Recommended: Introduction to sickle cell anemia
Sickle Cell Disease: An Overview
Sickle Cell Disease is a genetic disorder in which the body produces sickled shaped red blood cells. In sickle cell disease, or SCD, the hemoglobin in red blood cells groups together. This causes red blood cells to become stiff and C-shaped. These sickled cells prevent blood and oxygen flow in blood vessels, and collect in the blood vessels of the limbs and organs, impeading proper oxygenation of the blood. The most common signs and symptoms are linked to anemia and pain. Other signs and symptoms are linked to the disease's complications.
Sickle Cell Disease is most common in people whose families come from Africa, South or Central America (especially Panama), Caribbean islands, Mediterranean countries (such as Turkey, Greece, and Italy), India, and Saudi Arabia. In the United States, it's estimated that sickle cell anemia affects 70,000–100,000 people, mainly African Americans. The disease occurs in about 1 out of every 500 African American births. Sickle cell anemia also affects Hispanic Americans. The disease occurs in
The three most common types of SCD are HbSS, HbSC, and HbS beta thalassemia. People who have the HbSS mutation inherit two sickle cell genes (“S”), one from each parent. This is commonly called sickle cell anemia and is usually the most severe form of the disease. People who have HbSC inherit a sickle cell gene (“S”) from one parent and from the other parent a gene for an abnormal hemoglobin called “C”. This is usually a milder form of SCD. HBT occurs when a person inherit one sickle cell gene (“S”) from one parent and one gene for beta thalassemia, another type of anemia, from the other parent. There are two types of beta thalassemia: “0” and “+”. Those with HbS beta 0...
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..., Facts - NCBDDD. (n.d.). Retrieved from http://www.cdc.gov/ncbddd/sicklecell/facts.html
Kark, J. (2000). Sickle Cell Trait. Retrieved from Harvard.edu website: http://sickle.bwh.harvard.edu/sickle_trait.html
Sickle cell anemia Causes - Diseases and Conditions - Mayo Clinic. (n.d.). Retrieved from http://www.mayoclinic.org/diseases-conditions/sickle-cell-anemia/basics/causes/con-20019348
What Is Anemia? - NHLBI, NIH. (n.d.). Retrieved from https://www.nhlbi.nih.gov/health/health topics/topics/anemia/
Protective Effects of the Sickle Cell Gene Against Malaria Morbidity and Mortality. Aidoo M, Terlouw DJ, Kolczak MS, McElroy PD, ter Kuile FO, Kariuki S, Nahlen BL, Lal AA, Udhayakumar V. Lancet 2002; 359:1311-1312.
Source: Sickle cell disease | University of Maryland Medical Center http://umm.edu/health/medical/reports/articles/sickle-cell-disease#ixzz2zVvWvFkz
Malaria survives on healthy red-blood cells and carriers do not have a lot of healthy red-blood cells. Similarly to how those with hemochromatosis starved the bubonic plague of iron, sickle cell anemia carriers starve malaria of red-blood cells. The proactive effect of malaria only works on those who have one copy of sickle cell anemia and not the actual illness. If one has sickle cell anemia, one is more likely to get malaria. Nonetheless, malaria is such a vicious disease that anything that can aid in the fight against it and towards survival and reproduction is helpful.
1. Sickle Cell Disease is life-threatening and has a risk of of causing depression. In this study I examine the experiences that Sickle Cell patients go through specifically at emergency healthcare facilities to find out if there are any negative stigmatizations surrounding this disease. There may be judgments that are made about these patients from healthcare professionals when they seek drugs for their pain relief that may cause the stigmatization to occur. I will also investigate why individuals that have Sickle Cell Disease experience longer waiting times at emergency healthcare facilities and the lack of control they may have over their care regime.
What is Sickle cell disease? Sickle cell affects a disease; that disease is called which affects the hemoglobin when the red blood cells that send oxygen through the body are killed off and weakened. Sickle cells can be found in every 1 and 1000 African Americans, it is affecting about 70,000 to 80,000 Americans in the United States. Sickle cell is a death threatening disease, and the severity of symptoms can vary from person to person (Sickle cell disease (SCD), 2015). Some people have light conditions, but others can have severe conditions, which, mean they could be hospitalized. Characteristics of this disease are caused by a minimum of low blood cells, which is called anemia.
Sickle cell anemia is a disease that has to be inherited from both parents. Both parents have sickle cell trait, which means each parent has sickle hemoglobin and normal hemoglobin. So people with the sickle cell trait can pass the sickle cell gene to their children. Most families that come from Africa, South Central, and Central America are more common with sickle cell anemia. According to National Heart, Lung and Blood, it’s estimated that the sickle cell disease has affected 70,000-100,000 people mainly African Americans (National Institute of Health, 2012). Hispanic Americans also are common to having sickle cell anemia. According to National heart, Lung, and Blood Institute, statistics shows sickle cell anemia occurs in about 1 out of every 500 African American births and 1 out of 36,000 Hispanic American births (National Institute of Health, 2012). Signs of sickle cell anemia don’t show until after 4 months of age. Sickle cell anemia begins from ...
During a short break of solitude from studying, I explored and came across that the environment in which most African Americans reside in has a high occurrence of malaria virus. The malaria virus disease is contagious and when it contaminates someone with sickle cell traits, it cannot survive on the external part of the human body so therefore the individual doesn’t develop the deadly malaria virus. While looking further into our class textbook on Human Genetics 11th Edition by Ricki Lewis, and this issue of sickle-cell among the African Americans, I
Hemoglobin SS happens because of a mutation in chromosome 11. Chromosome 11 contains the gene of hemoglobin-Beta. Hemoglobin (HBB) transports oxygen to your body parts like your lungs. Hemoglobin contains 2 alpha hemoglobin and 2 beta hemoglobin chains. Sickle cell anemia results from a point mutation. There is a change in the sixth amino acid in the beta hemoglobin chain from GLU to VAL. The Hemoglobin S gene is then resulted from this and is a rece...
Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
Sickle cell anemia is an inherited disease of red blood cells. Normally red blood cells contain a protein called hemoglobin A, which carries oxygen to all the organs in the body. With sickle cell anemia, however, the body makes a different kind of protein, called hemoglobin S.
As of 2013 an estimated study showed that over 100,000 people living with sickle cell anemia in the United States. One out of thirteen babies born to an African American parents will inherit the trait and one out of three hundred sixty five African American babies will be born with the disease. This is not just a black disease many Hispanics, Middle Eastern and individual with Asian background are also
Sickle cell anemia is a genetic disorder. For a person to have sickle cell anemia they must have received two copies of the gene, one from each parent. A person with the sickle cell trait only received one sickle cell gene and a normal hemoglobin gene. People who have the sickle cell trait do not develop sickle cell anemia however they can pass the deformed gene on to their children. People with just the trait do not face the complications caused by the disorder.
Sickle Cell Anemia seems to be one of the hardest conditions to live with due to the severity of its symptoms and it can be an encumbrance to everyday life. Although this condition is hard to live with, it is possible to live with it. Thanks to the twenty-first century advancements, there is great medical care available to patients and many other resources and support groups to help families through this harsh reality of living with sickle cell. Perhaps one day there will be a readily available cure for this horrible disease. Until then, a patient with sickle cell should have a support system and take care to live a healthy life so that they can live their life to the fullest.
Sickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow as crescent shaped red blood cells. Unlike normal red blood cells, sickle shaped cells are unable to deliver much oxygen to other parts of the body due to the abnormal hemoglobin. Sickle cell’s are stiff and sticky and tend to clump together between blood vessels that can cause pain, damage to the organs, and infections. If a child inherits this disease they can be healthy throughout their life or need special care. “In the United States, SCD is most common among blacks and Hispanics. SCD affects about 1 in 500 black births and about 1 in 36,000 Hispanic births in this country. SCD is also common among people with family from Africa, the Caribbean, Greece, India, Italy, Malta, Sardinia, Saudi Arabia, Turkey or South or Central America (March of Dimes)”.
Hamosh, A. (1999, June 13). OMIM Entry - # 603903 - SICKLE CELL ANEMIA. OMIM Entry - # 603903 - SICKLE CELL ANEMIA. Retrieved April 26, 2014, from http://www.omim.org/entry/603903?search=sickle%20cell%20anemia&highlight=cell%20anemia%20anaemia%20sickle
The second one is beta thalassemia. This occurs when similar gene defects affect production of the beta globin protein. It happens mostly in people of Mediterranean origin, Chinese, other Asians, and African Americans. You need both alpha- and beta-globin to make hemoglobin. If you have one damaged gene, you may have mild anemia and probably won't need treatment. This is called beta thalassemia minor or beta thalassemia trait. It happens when you get a normal gene from one parent and a thalassemia gene from the other. When both genes are damaged, it means you got a thalassemia gene from each parent. You may have moderate or severe anemia. If you have moderate anemia, you may n...