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The Process of Apoptosis Essay

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Introduction
As creatures of the light, it is natural for us to fear the dark unknown of death. However, if we only knew how prevalent death is in our lives, perhaps we would not be so afraid or disgusted by it. For it is death that keeps our body running functionally, and giving the organ systems physical definition, enabling them to work properly. The building blocks of our bodies-- cells-- are alive and constantly growing, and if they continued to do so without pause, our organ systems would become enlarged and misshapen, and we as an unified organism would die. Therefore, our cells commit suicide on a regular basis via programmed cell death, more commonly referred to as apoptosis; this is done either to cull excess cells to give way to new ones, or when cells start malfunctioning and don’t want to reproduce. Apoptosis should not be confused with its foil, cell necrosis, which is is another death system that kicks in when cells and tissues are dealt trauma, and it is highly irregular, as opposed to the regulated apoptosis. Each death system has its own purposes in the body, and the interruptions of these small deaths can ultimately lead to the death of the entire organism-- life is not merely followed by death-- it is supported by it.
The apoptosis process is a fairly recent medical discovery, as intensive research had only begun in the late 1900s, leading Drs Brenner, Horvitz and Sutton to their ground-breaking discoveries in the field, earning them the Nobel Prize in Medicine (Hung and Chow, 2004). Their research began in Caenorhabditis elegans, which has more simple DNA and body processes than mammals. However, it was soon discovered that the genes which regulate apoptosis in the nematode are similar to those in large orga...


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...nical and Investigative Medicine 27.6 Dec 2004: 324-44. Proquest. Web. 5 April 2014.
Joza, Susin, et al. “Essential Role of the Mitochondrial Apoptosis-Inducing Factor in
Programmed Cell Death”. Nature 410.6828 29 Mar. 2001: 549-54. Proquest. Web. 19 March 2014.
Leach, Argie P. “Apoptosis: Molecular Mechanism for Physiologic Cell Death”. Clinical
Laboratory Science 11.6 Nov./Dec. 1998: 346-9. Proquest. Web. 19 March 2014.
Ola, Muhammad Shamsul, Mohd. Nawaz, Haseeb Ahsan. “Role of Bcl-2 Family Proteins and
Caspases in the Regulation of Apoptosis”. Molecular and Cellular Biochemistry 3511-.2 May 2011: 41-48. Proquest. Web. 6 April 2014.
Zheng, Jia, et al. “Mesothelin Regulates Growth and Apoptosis in Pancreatic Cancer Cells
Through P53-Dependent and -Independent Pathway”. Journal of Experimental and Clinical Cancer Research 31 (2012): 84. Proquest. Web. 6 April 2014.



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