NSAID`s and Immunotoxicity

1350 Words3 Pages

Immuno-toxicity:

It is defined as a condition where an immunotoxin adversely affects immune system. An Immunotoxin is a human made protein which consists of protein linked to a toxin. The protein acts in “targeting” specific cells, which are killed when the protein binds to such cells and the toxin is taken in through a process called “endocytosis”. Immunotoxicity comprises direct toxicity to components of the immune system, resulting in suppressed function or inadvertent stimulation.

The immune system consist of complex network of cells and soluble mediators that interact in a highly regulated manner to generate immune responses, consequently inappropriate immune responses might lead to allergic and auto immune diseases.

NSAIDs:

NSAIDs (Non-steroidal anti-inflammatory drugs) have antipyretic and anti-inflammatory actions in different measures. They act mainly on peripheral pain mechanisms and do not cause physical dependence or depress CNS. Although the risk of adverse effects from NSAIDs increases with long term usage, they are a reliable and effective treatment for control of moderate pain. The most common NSAIDs are aspirin, phenylbutazone, diclofenac, paracetamol, ibuprofen, and ketoprofen.

Few NSAID`s and there structures:

Aspirin

Uses: Besides, having regular antipyretic and anti-inflammatory effects, it is believed to have antioxidant effects (Ataollah, 2011) via its ability to scavenge-OH radicals.

Ibuprofen:

Uses: Migraine treatment (Evers, 2011)

Paracetamol:

Uses: Most common household drug

Mechanism:

There are different types of cyclooxygenase (COX) enzymes i...

... middle of paper ...

...Early Pregnancy Linked to Risk for Miscarriage, Canadian Medical Assosciation Journal, 110454.

4. Mennear, John H, White, Kimber L,; Komocsar, Wendy J.; Khan, K. Nasir;. Jr.; Furst, Sylvia M.; Peachee, Vanessa L.; Screening drugs for immunotoxic potential: I. Assessment of the effects of conventional nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors on in vitro and in vivo phagocytic activity, 2004, Vol-1,149-158.

5. Kushima, Kiyoshi; Fujiwara, Michio; Oda, Keiko; Sakuma, Shozo; Furusawa, Shuichi; Effect of prenatal administration of NSAIDs on the immune response in juvenile and adult, 2007, Vol-232,257-267.

6. PanahYab, Ataollah ;Bagheri Sadeghi, Golshan; Nafisi, Shohreh; Interaction of aspirin and vitaminc with bovine serum albumin,2011,105,198-202.

7. Husstedt, I. W.; Evers, S. Migraine during pregnancy and breast feeding, 2011, 44, 969-973

More about NSAID`s and Immunotoxicity

Open Document