Lyme disease: An Emerging Infectious Disease

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Disease and Pathology

Lyme disease, or lyme borreliosis, is an emerging infectious disease transmitted by ticks. Lyme disease is considered an emerging infectious disease because it’s incidence has increased over the past 20 years, and it was not identified until 1975 in the United States (CITE). Lyme disease is the most commonly reported vector-borne disease in the United States. Lyme disease causes symptoms similar to that of influenza, and includes headache, chills, fever, lethargy, and muscle pain in the initial stages. A bulls-eye shaped rash at the site of the tick bite can also occur in those infected, but not all infected persons develop the rash. The rash typically develops three to thirty days after the person is bitten. Later symptoms of Lyme disease include joint inflammation, stiff neck, body itching, and strange or unusual behavior. If left untreated Lyme disease can cause more severe long lasting problems such as permanent paraplegia, Lyme encephalopathy, psychosis, and Lyme arthritis (CITE). Lyme disease is rarely fatal, but incidence rates of 7 to 9.7 per 100,000 people have been reported. Transmission is not common, since only about 1% of recognized tick bites result in Lyme disease. It is possible that transmission is low because an infected tick must be attached for at least a day for transmission to occur. The incidence rate of Lyme disease varies from geographic location to location since ticks have particular ecological niches (CITE).

Agent

Lyme disease is caused by Gram-negative, spirochete bacteria from the genus Borrelia. The bacteria can spread throughout the body during the course of the disease. Areas the bacteria have been indentified include the skin, heart, joints, and both the peripheral and c...

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... population (CITE).

A vaccine was produced for use in the U.S. in 1998 but was withdrawn from the market by the manufacturer in 2002. Problems included poor demand, high cost, the need for a series of 3 vaccinations and boosters to maintain high titers, insufficient titers in approximately 5% of recipients, and theoretical concerns that vaccination might increase the risk of autoimmune arthritis. A 2nd-generation vaccine is being studied (CITE).

In Florida, 554 cases of Lyme disease were reported from 1999 through 2008 (average 55 cases per year), but the prevalence of Lyme disease is higher in other areas. During 1992--2006, a total of 248,074 cases of Lyme disease were reported to CDC by health departments in the 50 states, the District of Columbia, and U.S. territories; the annual count increased 101%, from 9,908 cases in 1992 to 19,931 cases in 2006 (CITE).

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