Gene Therapy
I. Introduction
With the human genome project now completed, identifying our DNA, the next step forward is being taken to analyze this information and apply it in a helpful context. As we discover which genes affect and trigger the different traits humans possess, new questions result pertaining to potential problems in our DNA as well as genetic enhancement opportunities. In theory, once a problem is pinpointed within a person’s DNA, there exists a possibility for correcting this defect. Gene therapy is a technique used for correcting defective genes responsible for disease development. This relatively new idea sparks much controversy when societal implications are examined. Bill Joy, chief scientist and co-founder of Sun Microsystems, comments that “we can easily imagine an arms race developing over GNR [genetics, nanotechnology, and robotics] technologies, as it did with the NBC [nuclear, chemical, and biological] technologies in the 20th century….This time…we aren't in a war …we are driven, instead, by our habits, our desires, our economic system, and our competitive need to know (Joy, 2000)."
This paper provides an in depth look at gene therapy including a description as well as an examination of gene therapy as it affects societal issues. Faced with different applications for the recent knowledge gained in gene therapy, ethical considerations must be analyzed so that society can move forward with caution.
II. Gene Therapy Review
Gene therapy, with its first clinical trial in 1990, is a relatively new field that leaves much open to be explored. The idea of gene therapy focuses on locating the defective gene and treating it so that the fixed gene functions correctly by producing prot...
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Increasingly over the past two decades and in part thanks to the publication of James Davison Hunter’s book, Culture Wars: The Struggle to Define America, the idea of a culture war in American politics has been gaining attention. While the tension between conservatives and liberals is palpable, it’s intensity has proven hard to measure. However, it doesn’t seem that many Americans are polarized on the topic of polarization as most would agree that the culture war is real (Fiorina, 2005). This thinking is what prompted Morris Fiorina to write the book Culture War? The Myth of a Polarized America. In it, Fiorina outlines an argument against the idea of a culture war by looking at party affiliation by states, how public opinion on hot button issues changed over time and various explanations for why Americans are so hung up on the topic of polarization. While Fiorina makes a good argument, the evidence supporting the culture war is too powerful to explain away.
The Battle of Takur Ghar was a short but intense military engagement between United States special operations forces and al Qaeda insurgents fought in March 2002, at the top of the Takur Ghar Mountain in Afghanistan. The Battle proved to be the deadliest entanglement of Operation Anaconda, an effort early in the war in Afghanistan to route al Qaeda forces from the Shahi-kot Valley and Arma Mountains. The battle saw three U.S. Helicopters landing on the mountain top, each greeted by direct fire from al Qaeda forces. Although the mountain was eventually taken, seven U.S. service members were killed and many other wounded. In honor of the first casualty of this battle, Navy Seal Neil C Roberts, the battle is also known as the Battle of Roberts Ridge.
Guy de Maupassant expresses his theme through the use of situational irony. Guy de Maupassant says, “She suffered endlessly, feeling herself born for every delicacy and luxury. She suffered from the poorness of her house. All these things, of which other women of her class would not even have been aware, tormented and insulted her.”(De Maupassant). She is poor and thinks of herself too much and then he says "but she was as unhappy as though she had married beneath her; for women have no caste or class.”(De Maupassant). She wants more than she can get which will ruin her later in the story. When she lost the necklace by the end of the week they had lost all hope to find it. Loisel, who had aged five years, declared:
Fashion of the 1920’s was also known as the roaring 20’s. Fashion in the 1920’s became more relaxed in the 20’s. In the early 1920’s the normal fashion was dropped waistlines, long, cylindrical skirts, 7” to 10” below the knee. Women finally received the right to vote, with this new right women also
...ne starts life with an equal chance of health and success. Yet, gene therapy can also be thought of as a straight route towards a dark outlook, where perfection is the first priority, genes are seen as the ultimate puppeteer, and personal freedom to thrive based on one’s self isn’t believed to exist. With the emergence of each new technological discovery comes the emergence of each new ethical debate, and one day, each viewpoint on this momentous issue may be able to find a bit of truth in the other. Eventually, our society may reach a compromise on gene therapy.
In 1957, the army began developing a new fighting force based on the helicopter. ...
Despite being magical of gene therapy, it is high-risk. Few people got benefits from it, and it has a low rate of success. Prior to the human trial, Batshaw and Wilson had done experiment on animals to ensure the safety. Over 20 experiments have been done on mice but only 12 of them survived at last (Sophia, M. and Kolehmainen, J.D., 2000). More seriously, complicating diseases, which can be more dangerous than genetic diseases, might set in during the treatment period. In December 200...
Gene therapy is a technique used in attempts to cure or prevent genetic diseases at the molecular level (basically at the source) by correcting what is wrong with defective genes, a good version of the defective gene is introduced into the existing cells. This technique is still considered experimental, only being done through clinical trials. This idea was first suggested during the 1950’s. The basic idea was “if the basses can be arranged incorrectly then why can’t they be rearranged in the correct way?”
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Mathilde Loisel lived the life of a painfully distressed woman, who always believed herself worthy of living in the upper class. Although Mathilde was born into the average middle class family, she spent her time daydreaming of her destiny for more in life... especially when it came to her financial status. Guy de Maupassant’s short story, “The Necklace”, tells a tale of a vain, narcissistic housewife who longed for the aristocratic lifestyle that she believed she was creditable for. In describing Mathilde’s self-serving, unappreciative, broken and fake human behaviors, de Maupassant incorporates the tragic irony that ultimately concludes in ruining her.
It is said that “everything that shines isn't gold.” A difficult situation can result a vast illusion that is not what one thought it would be, which leads to disappointment and despair. Just like Guy De Maupassant stories, “The Necklace” and “The Jewel.” In the first story, the protagonist, Mathilde Loisel’s need for materialistic fulfillment causes her hard labor which ends her natural beauty. In the second story, the husband Monsieur Latin ends up living a dreadful life due to the passing of his wife and her admiration for jewels. “The Necklace” and “The Jewel” both share many similarities such as the unconditional love each husband haves toward their wife, the necessity each wife haves towards materialistic greed, the beautiful allurement
Scientists and the general population favor genetic engineering because of the effects it has for the future generation; the advanced technology has helped our society to freely perform any improvements. Genetic engineering is currently an effective yet dangerous way to make this statement tangible. Though it may sound easy and harmless to change one’s genetic code, the conflicts do not only involve the scientific possibilities but also the human morals and ethics. When the scientists first used mice to practice this experiment, they “improved learning and memory” but showed an “increased sensitivity to pain.” The experiment has proven that while the result are favorable, there is a low percentage of success rate. Therefore, scientists have concluded that the resources they currently own will not allow an approval from the society to continually code new genes. While coding a new set of genes for people may be a benefitting idea, some people oppose this idea.
Maupassant, Guy De, and Joachim Neugroschel. The Necklace and Other Tales. New York: Modern Library, 2003. Print.
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