Estrogens are among the most important hormones in the female body, which pass through distant organs, interact with multiple organ systems, and play a pivotal role in the physiologic events that occur during a woman’s life. [1] Presence of endogenous hormones in the plasma poses challenges for the pharmacokinetic and bioanalytical considerations in terms of endogenous baseline levels, low plasma concentration, analytical range, and possible effect of circulating hormones. In order to quantify plasma concentrations of estrogens in clinical trials, it was necessary to develop and validate an assay with appropriate sensitivity, selectivity, accuracy and precision. [2]
OBJECTIVE:
The objective of the present study is to develop the more sensitive, rapid and simultaneous quantification of estrogen i.e. Estradiol (E2) and Estrone (E1) in human plasma.
EXPERIMENTAL METHODS:
1. Chemicals: The pure substances of Estradiol, Estrone were procured from the council of Europe, (Strasbourg, Cedex). Amlodipine besilyate (internal standard) procured from Sigma-Aldrich. Dansyl chloride wa...
“High levels of hormones can cause problems in the human body, but can hormones we ingest really alter our hormone level...
Considering the variation in clinical presentation of PCOS there was no fixed diagnostic criteria available until 1990. In April 1990 National Institutes of Health (NIH) held a conference and defined Polycystic ovary syndrome (PCOS) as having 1) hyperandrogenism, 2) oligoovulation, and 3) exclusion of known dis...
There has been conflicting research and advice about the safety of hormones with the increase in the aging female population within the last twenty years (National Institute on Aging). Hormone therapy has demonstrated to be the most effective FDA approved medication in the relief of menopausal symptoms, but these benefits must be weighed against serious adverse effects that hormones can cause. Although many women differ in their response to hormone products, MHT has been universally linked to an increased risk of heart disease, heart attack, blood clots, and strokes. Concerns about the findings discovered in the clinical and observation trials performed on MHT, have left some doctors and women hesitant in utilizing MHT to combat menopausal symptoms.
The endocrine system is very dynamic and has ties to most, if not all of the other major systems of the body. It is responsible for production of hormones and the regulation of them as well. These hormones act as chemical messengers within the body. Through several differing mechanisms, they are able to trigger very specific responses in target cells or organs. This is what enables the endocrine system to guide growth, development, reproduction, and behavior, among many others as well.
Women's Brain When you look at the dictionary, the definition of 'Science' is "a branch of knowledge or study dealing with a body of facts or truths systematically arranged and showing the operation of general laws" (Webster's dictionary). In order to make a truth, many scientists take the time to observe or test with scientific methods. In the nineteenth century, there are some incorrect truths, even if it looks like truths logically arranged by scientific method, because the scientists understood the priori that already assumed the outcome would be the same as their predictions. As I read Stephen Jay Gould's argument from "Women's Brains", he found some unequal conditions that supported scientific method for intelligence of man. Paul Broca tried to measure the inferiority of women with scientific criteria that were invidious comparisons such as races, classes, and sexes.
In the early 1980’s breast implants began gaining popularity, but they have been on the market since the early 1960’s. They were invented by plastic surgeons Cronin and Gerow. Dow Corning began manufacturing them commercially in 1962. Today over two million women have undergone breast augmentation surgery. There are many negative consequences that may arise from the surgery, and there is always the risk of infection or rupture. When beginning my research on the subject I assumed there would be a plethora of information. I was shocked to find out that there wasn’t. Silicone breast implants have been around for 40 years and there have been very few studies on their consequences, and possible effects on a woman’s body. The Food and Drug Administration has never approved the use of silicone implants. It is a surprising fact, because silicone implants are still being used today, but only by women who agree to be in a study of their safety. The politics surrounding breast augmentation are sketchy for lack of a better word. They have been promoted as being safe, yet their safety has never been fully questioned. While looking online, I found a variety of websites on the subject. There were many websites from the plastic surgery industry promoting breast implants as being safe. Then there were the websites like http://www.siliconeholocaust.org, this was by far the most disturbing site I have ever seen. There were dozens of pictures of real women who had their lives ruined by breast implants. If these, and other women had the little information that is available on the subject, they may have opted not to have the surgery because of the unnecessary consequences they now suffer.
Administration, U.S. Food and Drug. Animal and Veterinary. 02 Febuary 2014. Web. 17 Febuary 2014.
It is said that the cause of PCOS is not known exactly, however, researchers and clinicians believe that PCOS tends to occur in women whose ovaries produce more male hormones than female hormones. In fact the outward signs and symptoms can be that of too much facial and body hair, weight gain, and darkening and/or thi...
Associating hormones with a certain gender can be a bit of a misnomer, as women also make testosterone, although in much smaller amounts. Likewise, the liver converts some of a man’s testosterone and fat tissue into estrogen.
Schramm, 2011). Another article had study on morphological development and characterization of aromatase and estrogen receptors alpha and beta in fetal ovaries of cattle. In this study the aim was to understand the role of estradiol-17β in fetal ovarian development, presence an localization of cytochrome p450 aromates (P450arom) and estrogen receptors alpha and beta proteins characterized in fetal ovaries of cattle. In the day of 110 of the experiment ovarian structures within different lobes appeared to be different morphological development stages. At the end of this experiment morphological development had analyzed that in granulosa cell growing of oocytes of follicles. Also both ERα and ERβ protein was observed in overigerous cords and granulosa cells and oocytes of follicles. (Burkart, 2009) Similar research had done by Celine Ferre, was “comparison of early morphological and molecular changes induced by 17-alpha-methytestosterone and estradiol benzoate in rat ovary.”(Ferre, 2013) The goal of this experiment was to identify early events and linked to morphological change in the ovary by exposure t...
A man has been married to his wife for seven years. The couple has two beautiful children, a fabulous home, and appear to have the perfect marriage. After the husband leaves work one afternoon, he decides to stop in at the local bar. The man sits at a table in the corner of the room. Not long after his arrival, a woman approaches him. She asks the man if she can join him at his table. The two seem to have quite a bit in common and enjoy each other’s company. The woman asks if he would like to go back to her apartment. He has not had a fight with his wife today. In fact, she surprised him with a love note in his briefcase. Their sex life is enjoyable, frequent, and without complaint. The couple is not currently having financial problems. Despite this, why did the man decide to leave with a stranger and cheat on his wife? A great deal of research has been carried out on the topic of infidelity. Marital therapists have reported that more than half of the couples they counsel are in therapy as a result of infidelity (Atkins, Jacobson citation). Therapists also consider an extramarital affair as, “one of the most damaging relationship events and one of the most difficult problems to treat in couples therapy” (whisman predicting sexual infidelity…). Some therapists estimate that 50% to 65% of couples seek help after an incident of infidelity in their relationship (Atkins, Jacobson & Baucom). Identifying the reasons for this problem are essential to the success of its reduction. Infidelity is not a new phenomenon. However, there was little research on the topic until the late 1970’s (Drigotas & Barta, 2001). Numerous factors have been examined while trying to determine the root cause for extramarital relationships a...
During recent years, numerous newspaper and magazine articles have suggested that humans may be at risk because small amounts of well known environmental contaminants, such as dioxin, PCBs and DDT, can affect hormone levels. Hormones are produced by the endocrine system as regulators of biological function in target organs. Because hormones play a critical role in early development, toxicological effects on the endocrine system often have an impact on the reproductive system. The term endocrine disruptor is used to describe chemicals that can mimic hormones and may either enhance or counteract their effects. It has been suggested that these hormone changes can, in turn, lead to a variety of health problems including cancer, decreased fertility, and abnormalities in newborns.
Testosterone is an androgen hormone that is secreted by the testes in men and ovaries and adrenal glands in women.1 This hormone interacts with the nervous system and assists in stimulating protein synthesis, inhibiting protein degradation, and allowing for muscle hypertrophy. 1, 2 In males, testosterone levels are highest in the mornings and wane throughout the day; however, there is a lower concentration of testosterone with limited variation in women throughout the day.1 Intensity, volume,
The cause of endometriosis continues to remain unknown. It has been researched for many decades and...