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Ethical concerns for forensic dna
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Introduction
The concept of DNA testing has expanded throughout the last several decades, and attention needs to be paid to the methods and implications of storing and using the samples. The human genome is a complex structure comprised of billions of base pairs. Only 0.1% of DNA makes up all of the differences in humans’ physical appearance (Pattock, 2011, p.855). Each person has about one hundred trillion cells, all of which contain chromosomes that make up an individual’s genome.
DNA from a Chromosome
In an article concerning Familial DNA Testing, A. Pattock (2011) examines the methods involved in DNA testing. Short Tandem Repeats (STRs), are non-coding genes that have stretches of varying numbers where copies of genetic sequences appear (p.854). STRs are identifiable quantities that can be used as a marker to make the comparison. Each STR forms an allele, which is part of a gene that is formed by a mutation and is found in the same position on a chromosome in every human (p.855). The loci, or fixed position, are the key to using alleles for DNA identification. Although all of the STR alleles put together comprise completely different people, not all of the STRs are unique. Because of this, multiple STR alleles need to be dissected (p.855, 856).
Loci on an Allele
Crime labs in the United States use 13 STR markers that are located over twelve chromosomes (p.856). In addition to the use of STRs, there are also different levels of searching: high, moderate and low stringency (p.858). Each type matches a different number of alleles from the sample to those in the database. High stringency searches match all 13 alleles, while moderate searches are designed case by case (p.858). Low and moderate stringency searches are consid...
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Lachter, K. (2009). Science and law: the implications of DNA profiling. Dartmouth.edu. (pp 1-8
). Retrieved from https://www.dartmouth.edu./~cbbc/courses/bio4-1997/KatieLachter.html
Michael, K. (2010). The legal, social and ethical controversy of the collection and storage of fingerprint profiles and DNA samples in forensic science. In K. Michael (Eds.), 2010 IEEE International Symposium on Technology and Society: Social Implications of Emerging Technologies, 48-60. Retrieved from http://works.bepress.com/kmichael/429/
Mitchener-Nissen, T. (2013). Addressing social resistance in emerging security technologies. Frontiers in Human Neuroscience, 7, (August 2013), 1-4. doi: 10.3389/fnhum.2013.00483
Pattock, A. (2011). It’s all relative: Familial DNA testing and the Fourth Amendment. Minnesota Journal of Law, Science & Technology, 12 (22), 851-77.
It is also thought that DNA fingerprinting and databases lead to racial disparities within the criminal justice system, since the majority of incarcerated persons are of African American or Latino decent (Chow-White). The ethical argument is that while DNA sample collections are legal and undoubtedly helpful in obtaining convictions, it on the other hand supports and in some ways promote racial disparities (Chow- White). At the urging of multiple anti-watchdog groups, legislation for changes in polices and institutional practices must be implemented to address these disparities and protect individuals within these demographics. The suggestion of encrypted digital codes that limit the information revealed by these databases to individuals are also being evaluated
Nowadays, DNA is a crucial component of a crime scene investigation, used to both to identify perpetrators from crime scenes and to determine a suspect’s guilt or innocence (Butler, 2005). The method of constructing a distinctive “fingerprint” from an individual’s DNA was first described by Alec Jeffreys in 1985. He discovered regions of repetitions of nucleotides inherent in DNA strands that differed from person to person (now known as variable number of tandem repeats, or VNTRs), and developed a technique to adjust the length variation into a definitive identity marker (Butler, 2005). Since then, DNA fingerprinting has been refined to be an indispensible source of evidence, expanded into multiple methods befitting different types of DNA samples. One of the more controversial practices of DNA forensics is familial DNA searching, which takes partial, rather than exact, matches between crime scene DNA and DNA stored in a public database as possible leads for further examination and information about the suspect. Using familial DNA searching for investigative purposes is a reliable and advantageous method to convict criminals.
Gest, Ted. " DNA "Fingerprinting " is Facing a Major Legal Challenge from Defense Attorneys and Civil Libertarians."
First and foremost is the Michael Mosley case. Michael Mosley was convicted murdering a couple ten years ago (Wurtman, 2011). Two other men were cleared when Mosley’s DNA was found at the scene of the murder (Crowe II, 2012). Also, there was a palm print on the wall and further DNA on the sheets in the bedroom (Wurtman, 2011). In contrast to all the evidence, Mosley’s attorney offered an alternative reason and painted a picture of different events to explain Mosley’s DNA’s presence (Wurtman, 2011). However, the jury didn’t buy the defense’s story, and Michael Mosley’s conviction led to a call for the DNA database to be worked on with the most interesting fact being that Michael Mosley had no DNA in the system until seven years later than the crime (Crowe II, 2012).
DNA analysis is a scientific process among the newest and most sophisicated of techniques used to test for genetic disorders, which involves direct examination of the DNA molecule itself (Lyman, 2014) . Today crime labs use mtDNA analysis. This type of analysis allows smaller degraded pieces of DNA to still be successfully tested (Lyman, 2014) . There are several steps taken when analyzing DNA in forensics. When testing scientists must first isolate the DNA so it is not contaminated and can't be used. Lab technicians the take small pieces of the DNA, conserving as much as they can encase they need to test again. Once testing is done the next step is determining the DNA test results and finally there is the comparison and interpretation of the test results from the unknown and known samples to determ...
Forensic genetics has other applications . The " fingerprint " DNA represents a valuable tool for forensic science . As is the case with an ordinary fingerprint genetic fingerprint is unique to each individual (except identical twins ) . The determination involves the observation of specific DNA sequences which can be obtained from extremely small tissue samples , hair, blood or eventually left at the scene . As Fifty microliters of blood, semen or five microliters of ten roots of hairs are enough , and nozzles secretions and cells from the fetus . In addition to its use in the capture of criminals , especially rapists , the genetic fingerprints can be used to establish family relationships . People involved in the conservation of species use them to be sure that captive breeding is among individuals who do not belong to the same family .
DNA profiles can be used to identify individuals, allowing evidence to be used both as a means of convicting the guilty and as a means of exonerating the innocent. People can leave traces of their DNA at a crime scene because it is inside every cell of their body. DNA can be extracted from blood, semen, saliva or hair roots left at a crime scene using a chemical process. Tiny amounts of DNA can be extracted from a single cell – such as cells shed from someone’s skin when they touch an object. Police can also collect biological samples from suspects, usually by scraping some cells from inside their cheek. If the DNA profile from an individual matches the DNA profile from a crime scene it is therefore highly likely that the blood, semen or saliva left at the crime scene came from them. Also, in a paternity test, the mother’s DNA profile is compared with the child’s to find which half was passed on by the mother. The other half of the child’s DNA is then compared with the alleged father’s DNA profile. If they don’t match, the ‘father’ is excluded, which means he isn’t the father of that child. If the DNA profiles match, the ‘father’ is not excluded - which means there is a high probability that he is the father. In both of these cases, the DNA profile is much like a “genetic fingerprint”, and if there are records kept such as birth certificates and social security numbers, then DNA profiles make just as much sense to keep.
The collection of DNA in an investigation is used most often to determine who the perpetrator(s) might be in a crime. There has been a rapid growth since its inception and legal and ethical issues have arisen. In the Double –Helix Double-Edged ...
Prime, Raymond J., and Jonathan Newman. "The Impact of DNA on Policing: Past, Present, and
To determine the balance between privacy and public safety legislation must address many questions including (but not limited to): when is a sample required to be obtained and by whom, is consent required, is force ever acceptable to obtain a sample, and which samples should be retained? Dr Katina Michael has reported that some instances that constitute acceptable DNA sample collection and storage (Table 4). The United States, England and Wales contain legislation that authorizes the collection of DNA from individuals arrested for violations of certain federal criminal laws and inclusion into the national DNA database of all profiles. Primary concerns focus these legal authorizations address privacy of a person and legal search and seizures of biological samples. For many countries like the United States there is a need to enact special legislation which led to delays in the implementation of DNA databases (Goodwin, et al., 2007, p102).
The Human Genome Project is the largest scientific endeavor undertaken since the Manhattan Project, and, as with the Manhattan Project, the completion of the Human Genome Project has brought to surface many moral and ethical issues concerning the use of the knowledge gained from the project. Although genetic tests for certain diseases have been available for 15 years (Ridley, 1999), the completion of the Human Genome Project will certainly lead to an exponential increase in the number of genetic tests available. Therefore, before genetic testing becomes a routine part of a visit to a doctor's office, the two main questions at the heart of the controversy surrounding genetic testing must be addressed: When should genetic testing be used? And who should have access to the results of genetic tests? As I intend to show, genetic tests should only be used for treatable diseases, and individuals should have the freedom to decide who has access to their test results.
Genetic screening techniques are coming of age and the controversy that surrounds them is growing by the minute. The definition of genetic screenings is as follows: a systematic search for persons with a specific genotype. These tests that look into the essence of humanity, will allow scientist and physicians the opportunity and ability to alter the human genotype for better or worse. Genetic advancements will bring controversy at every milestone. Genetic Screening usually takes place when an individu al or group shows risk for a disease or trait. Genetic testing can pinpoint a specific allelic interaction or multiple gene interactions, which may lead to a disorder. The common thread of life is DNA and DNA is the only major requirement for genetic sc reening. With knowledge of structure and function of DNA scientists can unlock the mysteries of life.
The debate over the importance of a Human Genome Project can be cleared up by looking at what the human genome actually is, and why knowing its DNA sequence can be beneficial to the scientific and the human community. The human genome is made up of about three billion base pairs, which contain about 100,000 genes. The 100,000 genes in the 46 human chromosomes only account for a small total of the DNA in our genome. Approximately 10 percent of our DNA make up these genes in our genome, these genes are what is actually encoded for and used by our body to make vital proteins needed for everyday life. The remaining 90 percent of our three billion base pairs are repeated sequences between genes that do not encode for any particular product. These repeated sequences account for the reason why 99 percent of any humans DNA is identical to another human's (1). With this knowledge many people believe it is not worth the time or money to sequence the entire human genome when only a small percent is used to encode for proteins. However, by sequencing the whole genome researchers will no longer have to do a needle in the haystack type of search for small genes, like the one found on chromosome four that is responsible for Huntington's disease (4). Also, knowing the complete human DNA sequence will allow scientists to determine the role and importance of the repeated DNA, non-protein encoding, sequences in our body.
Over 60 countries now have operating genetic databases that contain millions of people’s genetic information. There DNA is used for genetic studies and to identify genetic similarities in a family. This DNA can also be used to identify the perpetrator in a crime by comparing their DNA to the DNA found at the crime scene. But as gene banks have become more common around the world some have grown to question the sharing of this information internationally and the potential for hacking and abuse of the information.(yg, 2015) Gene banks have opened doors to many genetic discoveries, but they have constantly raised ethical questions pertaining to the privacy of one’s biological information and that the information could lead to potential discrimination.
The scientific and medical progress of DNA as been emense, from involving the identification of our genes that trigger major diseases or the creation and manufacture of drugs to treat these diseases. DNA has many significant uses to society, health and culture of today. One important area of DNA research is that used for genetic and medical research. Our abi...