Harpreet Singh
Introduction:
An astounding 347 million individuals (WHO-Danaei.G) are inflicted with Diabetes mellitus (DM), a type of metabolic disease that’s significantly influenced by hyperglycemia (causing individuals to generate high blood sugar) and can be characterized by the insufficient production or improper reaction to insulin. There are three different types of DM: Type 1, Type 2, and Gestational diabetes, all of which share common symptoms include polyuria (frequent urination), polydipsia (increased thirst), and polyphagia (increased hunger) (Ahuja 1139). Generally, diabetes prevents the ingested glucose from entering the cells, ultimately depriving the body of its’ main source of energy.
Type 1 DM is insulin-dependent and associated with the acute onset in age, caused through the insufficient production or excretion of insulin within the blood stream. Type 1 is uncommon, affecting approximately 5 – 10% of the population but requiring them to encounter daily insulin therapy and is most commonly seen in patients under thirty. Supporting evidence indicates that type 1 is more susceptible to environmental factors than previously thought, with possible causes including infectious viruses (e.g. Mumps, Rubella, Meningitis) (Cambridge 2). Recent advancement in increased understanding of the genetic basis behind type 1 has allowed researchers to indicate essential linkage and associations of HLA gene variants to type 1. Through this epigenetic modification and environmental factors, they will able to help associate the process by which these events implicate the groundwork’s for type 1 DM.
Type 2 DM is considered non-insulin-dependent and contains the vast majority of all diabetics, approximately 90 – 95%, wit...
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...into food, beverages, and the environment (Welshons).
Another easily identifiable factor in increasing the onset of DM are the epigenetic risk factors. The genetic susceptibility, caused by the missing genomic information, can be accounted by additional variants like histone posttranslational modifications, which remove or rearrange the histones bound with the DNA. DNA methylation alters the methylation levels of INS gene promoters and has been discovered in patients with TD1 that altered methylation of histones upstream of HLA-DRB1 and HLA-DQB1. Noncoding RNAs give rise to altered expression of miRNAs in regulatory T cells of T1D.
Many of the signs of Type 1 and Type 2 diabetes are similar. Possible symptoms include polyuria, polydipsia, polyphagia, fatigue, blurred vision, weight loss in T1D, and tingling/pain within hands and feet of T2D patients.
There are many symptoms of type one diabetes. They include drinking irritability, excessive urination, extreme weight loss, feeling very hungry or tired, sores that don’t heal and blurry eyesight. The cause of type one diabetes is unknown, although genetic tendency and childhood infections are two possibilities. The pancreas undergoes a change and cells that normally produce insulin are destroyed. This may be a result of the body’s own immune system believing the pancreas is a foreign organ. Also, type one diabetes often appears at times of physical stress and during illness when the body produces extra ...
During the year 1889, two researchers, Joseph Von Mering and Oskar Minkowski, discovered the disease that is known today as diabetes. Diabetes is a disease in which the insulin levels (a hormone produced in unique cells called the islets of Langerhans found in the pancreas) in the bloodstream are irregular and therefore affect the way the body uses sugars, as well as other nutrients. Up until the 1920’s, it was known that being diagnosed with diabetes was a death sentence which usually affected “children and adults under 30.” Those who were diagnosed were usually very hungry and thirsty, which are two of the symptoms associated with diabetes. However, no matter how much they ate, their bodies wouldn’t be able to use the nutrients due to the lack of insulin.
According to Lewis and associates, DM is a chronic disease that affects multiple body systems. For the purpose of this paper, only DM type 2 will be discussed based on the assumption that a majority of patients aged 60 years or older have this type. The primary defects of this disease consist of insulin resistance, decreased insulin production, inappropriate glucose production by the liver, and alterations in production of adipokines. Insulin resistance is the result of defects in the body’s insulin receptors. This finding predates all cases of DM type 2 and the development of impaired glucose tolerance. In insulin resistance, beta cells in the pancreas are stimulated to increase insulin production to compensate for the lack of response by the insulin receptors. Gradually, the beta cells begin to fail to secrete enough insulin to meet the body’s demands resulting in hyperglycemia. As a result of increased glucose in the liver, the liver begins to malfunction and release glucose at inappropriate times, thereby worsening hyperglycemia. Adding to the problem, glucose and fat metabolism is altered in adipose tissue, which is generally abundant in those with DM type 2. (Lewis et al., 2011)
Type 1 Diabetes formerly called juvenile onset diabetes occurs typically before the age of 20, but now at any age anyone can be diagnosed with type 1. Individuals with type 1 diabetes are usually thin, go to the bathroom a lot to urinate, and are always hungry. The cause of Type 1 Diabetes is that the pancreas, which is the organ that secretes insulin, is destroyed by auto antibodies, which is why people with Type 1 Diabetes always need insulin, either to be injected or through an insulin pump. When glucose cannot enter the cells, it builds up in the blood causing the body's cells to starve to death. People with type 1 diabetes mus...
Diabetes mellitus, habitually referred to as diabetes is caused by a decline in insulin secretion by the cells of the pancreatic islet resulting into a surge in blood glucose concentration, a condition known as hyperglycemia. Diabetes insipidus is a disorder defined by the secretion of huge quantities of highly diluted urine, this is regardless if a reduction in fluid intake. This is as a result of a deficit of anti-diuretic hormone (ADH) also known as vasopressin produced by the posterior pituitary gland. The disorder diabetes mellitus is associated by extreme reduction in weight, a higher urge for urination, also known as polyuria, higher levels of thirst (polydipsia) and an extreme craving to eat known as polyphagia. This disorder has been categorized as Type 1 or insulin dependent diabetes and Type 2 or non-insulin dependent diabetes another type is the Gestational diabetes. The Type 1 diabetes mellitus is portrayed by a deficiency of the insulin-secreting beta cells of the islets of Langerhans found in the pancreas, this leads to a shortage of insulin. The principal cause for this deficiency of beta cells is a T-cell mediated autoimmune onslaught. In children, Type1 diabetes is known as juvenile diabetes. The Type 2 diabetes mellitus is as a result of insulin resistance or diminished insulin sensitivity coupled to a reduction in insulin production.
The effects of a disorder with insulin can be very grave because this hormone is very important to the body. First I would like to discuss Diabetes Type 1. This disease, also called juvenile diabetes, is usually diagnosed to children or young adults. Off all the people with diabetes, only five percent of the people have type one diabetes. 10Type one diabetes is a condition in which the immune system destroys the cells in the pancreas which produce insulin. Type 1 diabetes is not associated with lifestyle habit; and it is neither curable nor preventable. So you my reader could receive this disease and never know how you got it or how to prevent it! At least you can know when you get though. Some of the symptoms are excessive thirst and urination,
Diabetes is a disease in which a person’s body in unable to make or utilize insulin properly which affects blood sugar levels. Insulin is a hormone that is produced in the pancreas, which helps to regulate glucose (sugar) levels, break down carbohydrates and fats, and is essential to produce the body’s energy. The CDC (2013) offers reliable insight, summarized here, into the different types of diabetes, some causes, and health complications that may arise from the disease.
Is a multisystem disease related to abnormal insulin production, impaired insulin utilization, or both. Diabetes Mellitus is a serious health problem throughout the world. It is the 5th leading cause of death in the U.S. It is the leading cause of heart disease, stroke, adult blindness, and nontraumatic lower limb amputations.
Most common people will see that they are suffering from type 2 diabetes. Unlike type 1 diabetes, type 2 is not because your immune system is attacking the insulin but is because your body simply does not produce the required insulin. 90% of people who have diabetes are diagnosed with type 2 (Medical News...
Diabetes refers to a set of several different diseases. It is a serious health problem throughout the world and fourth leading cause of death by disease in the country. All types of diabetes result in too much sugar, or glucos in the blood. To understand why this happens it would helpful if we understand how the body usually works. When we eat, our body breaks down the food into simpler forms such as glucose. The glucose goes into the bloodstream, where it then travels to all the cells in your body. The cells use the glucose for energy. Insulin, a hormone made by the pancreas, helps move the glucose from bloodstream to the cells. The pathophysiology of diabetes mellitus further explains the concept on how this disease works. Pancreas plays an important role of the metabolism of glucose by means of secreting the hormones insulin and glucagon. These hormones where then secreted by Islets of Langerhans directly to the blood. Inadequate secretion of insulin results on impaired metabolism of glucose, carbohydrates, proteins and fats which then result to hyperglycemia and glycosuria. Hyperglycemia is the most frequently observed sign of diabetes and is considered the etiologic source of diabetic complications both in the body and in the eye. On the other hand, glucagon is the hormone that opposes the act of insulin. It is secreted when blood glucose levels fall.
Type 1 diabetes is a lifelong auto-immune condition in which the body can't control the
Type 1 diabetes has a genetic onset that often occurs in adolescence (Porth, 2005). It is an autoimmune disease in which the insulin-producing beta cells within the liver are destroyed (Dorman, 1993). This causes a deficiency in insulin secretion, which ultimately leads to high blood glucose levels, also referred to as hyperglycemia (Guthrie & Guthrie, 2004). The mechanism for insulin deficiency leading to hyperglycemia is described in more detail in the following section and in Figure 1.
Symptoms are an indication of something being wrong. In the case of discovering juvenile diabetes, some symptoms include but are not limited to, being extremely thirsty, frequent urination, often feeling tired and or hungry. Some may experience unexplained weight loss, the delay of sores healing properly, dry and itchy skin may also occur. Others have had a feeling of tingling in their feet and even having blurred vision. The symptoms listed may be the first sign of type 1 diabetes, or may occur when the sugar is high. (Eckman 2011).
Diabetes mellitus also known simply as diabetes refers to a group of metabolic diseases which affect the body’s homeostatic mechanism used for maintaining and regulating the body’s blood sugar levels. Diabetes is a chronic condition which, in 2013 was estimated to be affecting 382 million people worldwide.[1] People suffering from diabetes are required to constantly be vigilant of their blood sugar levels to ensure it does not go below or above optimum levels. Depending on the type of diabetes and glucose level range, they may need to inject themselves with insulin or eat high sugar foods to restabilise their body. Failure to do so can lead to other long term health effects.[2]
On my mother’s side of the family Type-1 diabetes is prevalent and it isn’t entirely considered an inherited disease, but it has been proven to have some genetic factors that can be passed down. Diabetes is becoming an increasing problem in the United States with half of all Americans becoming either diabetic or pre-diabetic.