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Research on antibiotic resistance
Research on antibiotic resistance
The challenge of antibiotic resistance
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The Evolution of Antibiotic Resistant Bacteria
Since antibiotics, such as penicillin, became widely available in the 1940s, they have been called miracle drugs. They have been able to eliminate bacteria without significantly harming the other cells of the host. Now with each passing year, bacteria that are immune to antibiotics have become more and more common. This turn of events presents us with an alarming problem. Strains of bacteria that are resistant to all prescribed antibiotics are beginning to appear. As a result, diseases such as tuberculosis and penicillin-resistant gonorrhea are reemerging on a worldwide scale (1).
Resistance first appears in a population of bacteria through conditions that favor its selection. When an antibiotic attacks a group of bacteria, cells that are highly susceptible to the medicine will die. On the other hand, cells that have some resistance from the start or acquire it later may survive. At the same time, when antibiotics attack disease-causing bacteria, they also attack benign bacteria. This process eliminates drug-susceptible bacteria and favors bacteria that are resistant. Two things happen, populations of non-resistant and harmless bacteria are diminished, and because of the reduction of competition from these harmless and/or susceptible bacteria, resistant forms of disease-causing bacteria proliferate. As the resistant forms of the bacteria proliferate, there is more opportunity for genetic or chromosomal mutation (spontaneous DNA mutation (1)) or transformation, that comes about either through a form of microbial sex (1) or through the transference of plasmids, small circles of DNA (1), which allow bacteria to interchange genes with ease. Sometimes genes can also be t...
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... perspective must go beyond curing bacterial disease right now (3). This understanding must extend to the need to preserve microbial communities that are susceptible to antibiotics, so they will always be able to out-compete resistant strains.
Bibliography:
References
1) Lewis, Ricki, “The Rise of Antibiotic-Resistant Infections”. Food and Drug Administration Publication. http://ww.fda.gov/fdac/features/795_antibio.html September, 1995.
2) Levy, S., Bittner, M., and Salyers, A. “Ask the Experts”. Scientific American: http://www.sciam.com/askexpert/medicine/medice15.html.
3) Levy, Stuart B. “The Challenge of Antibiotic Resistance”. Scientific American: http://www.sciam.com/1998/0398issue/0398levy.html.
4) Zajicek, Gershom. “The Antibiotic Paradox: How Miracle Drugs Are Destroying the Miracle”. Plenum Press, N.Y. 1992.
Many countries in Europe collect data on the locations of antimicrobial resistance occurrences, the number of incidences , who uses antibiotics, and the health practitioners who may overusing the antibiotics so as to address the problem of anti-microbial resistance.
Antibiotic-resistant bacteria are created when mutations in the pathogen's genetic code occurs, changing the protein in the bacteria that the antibiotics normally go after into a shape that the antibiotic can not recognize. The average bacteria divides every twenty minutes, so if a contaminated spot has one single bacteria in the morning, there could be trillions on that same spot at the end of the day. That means that when counting all the possibilities of mutations, the amount of mutated offspring that the bacteria might have formed during those replications could be as high as in the millions. Fortunately though, this does not happen so frequently that it is normally an issue. The amount of non-mutated bacteria vastly outnumbers the mutated ones and many of the mutations occurring in the bacteria usually have either a harmful effect, or not effect at all on its function. That means that the pathogen is still relatively less harmful than it c...
According to USA Today, U.S. doctors are prescribing enough antibiotics to give to 4 out of 5 Americans every year, an alarming pace that suggests they are being excruciatingly overused. In fact, Dr. Aunna Pourang from MD states, “to give you an idea of how high the pressure is to prescribe antibiotics, I didn’t get a job once because during the interview I told the lead physician that I only prescribe antibiotic prescriptions when they are warranted.” The development and widespread obsession of antibiotics, or drugs that kill bacteria and thereby reduce infection, has helped billions of people live longer, healthier lives. Unfortunately, the more we rely on and abuse antibiotics, the more bacteria develop resistance to them, which makes treating infections that much more challenging and leads to the growth of drug-resistant strains of bacteria. Research from the Center of Disease Control found that two million people in the United States become infected with antibiotic resistant bacteria, while 23,000 people die from such infections each year. Americans often aren’t informed on the power of the human body and rush to assumptions when perfection isn’t present. In a nutshell, the obsession of antibiotics is quite deadly and needs to be addressed before it’s too
Long before humans discovered antibiotics, they existed in nature. So naturally, after penicillin was introduced, some germs were already naturally resistant to the drug. As we used more and more of the antibiotics, we incidentally caused drug-resistant germs to progress. So, even if you’ve never misused antibiotics, you could still become infected by bacterium most drugs won’t kill. For each drug, there are germs genetically programmed to survive- some w/ outer walls tough for antibiotic to cross, others with ways to dump the drugs back out before they can work, and yet others can inactivate the antibiotic. Even worse, by passing tiny packets of genetic material to other bacteria, these survivor germs sometimes also pass the formula for resistance to the other bacteria. The best way you can protect yourself and your family against drug-resistant bacteria is by using antibiotics correctly. Taking them when they’re not needed encourages the takeover of drug-resistant strains in your body. (Redbook, pg.95) That’s because when antibiotics are given, the normal bacteria in your body are killed off, leaving lots of bacterial “parking spaces'; open. And the germ left to fill them is the drug-resistant ones. (Redbook, pg.95) So far, antibiotic resistance has not been a big problem with streptococcus A, the germ familiar to all of us for causing millions of cases of strep thr...
Carroll. Even with widespread controversy over antibiotic resistance, Carroll remained neutral with his writing, pointing out facts that fit both sides of the argument. One of the most important issues addressed in the article was the lack of education when it comes to the proper use of antibiotics. The health of the public would benefit greatly from education about viruses and bacterial infections. Carroll’s article is a good resource for the basis of the topic’s education. The article informs readers about the importance of antibiotics and the development of antibiotic resistance as well as future prevention and research for antibiotic
Throughout history disease has run rampant taking many lives with every passing day. Finding a cure or even just a tool in the battle has been the main focus of scientist throughout time. This focus is what brought us the discovery of antibiotics. Over the years antibiotics have been misused by patients, over prescribed by physicians and have led to resistant strains of bacteria.
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
In the last decade, the number of prescriptions for antibiotics has increases. Even though, antibiotics are helpful, an excess amount of antibiotics can be dangerous. Quite often antibiotics are wrongly prescribed to cure viruses when they are meant to target bacteria. Antibiotics are a type of medicine that is prone to kill microorganisms, or bacteria. By examining the PBS documentary Hunting the Nightmare Bacteria and the article “U.S. government taps GlaxoSmithKline for New Antibiotics” by Ben Hirschler as well as a few other articles can help depict the problem that is of doctors prescribing antibiotics wrongly or excessively, which can led to becoming harmful to the body.
Every year, antibiotic-resistant bacteria are threatening more and more people. As much of a problem as it is, many people are not educated on the term drug resistance. Since it is such a growing concern, it becomes confusing as to why drug resistance is occurring and what can be done to prevent it. Because drug resistance is such a health problem, determining what it is, how these bacteria can acquire the antimicrobial agents, and the possible solutions to the resistance are the types of actions that need to be taken in order to have a better understanding of how truly powerful these drug resistant bacteria are.
Thesis: With the advent of antibiotics in 1929 Fleming said, "The time may come when penicillin can be bought by anyone in the shops.Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant."With the overuse of antibiotics today we have seen this very idea come to be.Over usage is caused most prevalently by a lack of education on the part of the patient.Thus stated, the way to overcome such a circumstance is to educate, not only the patient but also the physician.
There are many medical professionals who believe that the rise of antibiotic resistance is a result of the overuse and misuse of antibiotics. Dr. Jim Wilde, a paediatric emergency medicine physician at the Medical College of Georgia believes that the medical profession is losing the war against resistance...
Numerous studies indicate the surge of antibiotic-resistant diseases resulting from older strains of diseases. These bacteria have learned how to combat antibiotics. Furthermore, there is a “rapid emergence of new diseases.” Along with resurgence of older diseases, chronic diseases are still prominent. Scientists are working to find cures for chronic and degenerative diseases and resolve past
It is estimated that over one-half of the antibiotics in the U.S. are used in food animal production. The overuse of antimicrobials in food animal production is an under-appreciated problem. In both human and veterinary medicine, the risk of developing resistance rises each time bacteria are exposed to antimicrobials. Resistance opens the door to treatment failure for even the most common pathogens and leads to an increasing number of infections. The mounting evidence of the relationship between antimicrobial use in animal husbandry and the increase in bacterial resistance in humans has prompted several reviews of agricultural practices by scientific authorities in a number of countries, including the US.
The most effective way to combat pathogenic bacteria which invade the body is the use of antibiotics. Overexposure to antibiotics can easily lead to resistant strains of bacteria. Resistance is dangerous because bacteria can easily spread from person to person. Simple methods for preventing excessive bacterial spread are often overlooked. Not all preventative measures are even adequate. Doctors and patients often use antibiotics unnecessarily or incorrectly, leading to greater resistance. Antibiotics are used heavily in livestock and this excessive antibiotic use can create resistant bacteria and transfer them to humans. In order to reduce resistant bacteria,
“An interesting byproduct of the newer solutions to medical dilemmas is the slowly growing resistance of antibiotics in bacteria (“Externalities”, 2016)”. The person who is affected by the negative externality concerning the use of antibiotics by others will see it as lowered utility: either subjective displeasure or potentially explicit costs, such as higher medical expenses in the future to treat infections that could have otherwise been treated easily at a lower cost (Ditah, 2011). In order to mitigate antibiotic resistance, healthcare workers should stop prescribing antibiotics unless it’s truly necessary. Additionally, the government should make more of an effort to tackle antibiotic resistance. People should also be educated about how overuse is