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An Overview Of Sickle Cell Disease
Abstract for sickle cell anemia
An Overview Of Sickle Cell Disease
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Sickle Cell Disease is a condition where there is not enough healthy red blood cells to carry oxygen throughout the body. Another name for sickle cell disease is sickle cell anemia. Sickle cell anemia is inherited as a simple recessive condition. In normal red blood cells, the cells are usually flexible and round. However, in sickle cell disease the red cells become rigid and sticky. They are shaped like sickles or crescent moons. Because these cells are irregular, they can get stuck in small blood vessels. The small blood vessels slow or block blood flow. Without enough red blood cells in circulation a person's body cannot get the adequate amounts of oxygen needed to feel energized. There are many signs and symptoms of sickle cell anemia. The sickle cell disease usually shows up after an infant is approximately four months old. Anemia is one sign of sickle cell disease. Red blood cells usually live for 120 days before they need to be replaced by new ones. However, sickle cells die off after ten to twenty days. Another symptom of sickle cell anemia is episodes of pain. Episodes of pain are one of the major symptoms of sickle cell anemia. The pain develops because sickle-shaped red blood cells block the flow through tiny blood vessels to your abdomen, joints, and chest. These episodes of pain that occur periodically are called crises. Some patients diagnosed with sickle cell anemia only experience pain a few times in a year, whereas; others can experience various amounts of crises a year. Sometimes if the pain is severe patients may be hospitalized. The pain can also occur in the bones as well. To continue, hand-foot syndrome is also another symptom of sickle cell anemia. Usually a patient will have swollen hands and feet. The s... ... middle of paper ... ...ficance by the World Health Organization. To continue, 70 percent of sufferers of sickle cell disease live in Africa. Sickle cell disease is found more commonly in people who are descendants from the Middle Eastern, Indian, Mediterranean, and African heritages. This is because those geographic regions are most prone to malaria. The gene variant for SCD is related to malaria. Therefore, wherever malaria occurs there is sickle cell disease. It is also believed that people who carry the sickle cell trait are less likely to have severe forms of malaria. It is estimated that sickle cell disease will affect 90,000 to 100,000 American. Sickle cell disease affects a large percentage of people in Central America as well as significant numbers in South America such as Brazil, and the Caribbean. Sickle cell disease is the most frequently occurring genetic disease on the earth.
In the continent Africa, about 1 in 100 individuals develops this disease. We ask ourselves why is the frequency of a potentially fatal disease so much higher in Africa? The answer is related to another deadly disease, which is called malaria. Chills, fever, vomiting, and severe headaches characterize malaria (GENETICS Sickle Cell Case Study. (n.d.). 2000, October 19). Malaria is caused by a disgusting parasite called Plasmodium that is transmitted to humans by mosquitos. When the malaria parasites invade the bloodstream, the red blood cells that contain defective hemoglobin get sickle cell out and die (Facts About Sickle Cell Disease. 2014, January 16). This helps protect the individual with Sickle Cell Anemia from an infection of malaria. As you can see, this is why a variety of areas in the world has a high rate of malaria, such as
Sickle Cell Disease (SCD) (also known as Sickle Cell Disorder or Sickle Cell Anemia) is an inherited blood disorder where the red blood cells have abnormal sickle-shaped hemoglobin S (HbS) called sickle haemoglobin (National Heart Lungs and Blood Institute (NHLBI), 2015). The disease, according to medical sciences, is inherited from both parents as part of their genetic makeup and is usually caused by some abnormalities in haemoglobin which is a protein in red blood cells that conveys oxygen through the body. Whereas normal red blood cells are round, in people with sickle cell anemia, a defective substance in red blood cells changes the shape of the cells. The normal haemoglobin called haemoglobin A (HbA) is replaced by HbS which later becomes
Stem cells help us to maintain and heal our bodies, as they are undifferentiated cells, their roles are not yet determined. They have the ability to become anything during early life and growth. Stem cells come from two sources, namely: embryonic stem cells (embryo’s formed during the blastocyst phase of embryological development) and adult stem cells (see figure 3).
Sickle cell anemia is a disease that has to be inherited from both parents. Both parents have sickle cell trait, which means each parent has sickle hemoglobin and normal hemoglobin. So people with the sickle cell trait can pass the sickle cell gene to their children. Most families that come from Africa, South Central, and Central America are more common with sickle cell anemia. According to National Heart, Lung and Blood, it’s estimated that the sickle cell disease has affected 70,000-100,000 people mainly African Americans (National Institute of Health, 2012). Hispanic Americans also are common to having sickle cell anemia. According to National heart, Lung, and Blood Institute, statistics shows sickle cell anemia occurs in about 1 out of every 500 African American births and 1 out of 36,000 Hispanic American births (National Institute of Health, 2012). Signs of sickle cell anemia don’t show until after 4 months of age. Sickle cell anemia begins from ...
Thalassemia is an inherited blood disorder characterized by low amounts of hemoglobin and a low count of erythrocytes in the body. Thalassemia is caused by mutations in the deoxyribonucleic acid of cells, which makes hemoglobin. The mutations are passed from parent to child. The mutations vary depending on the type of Thalassemia inherited. The variation in the mutation occurs from the number of gene mutations, which are inherited, as well as mutation within the hemoglobin molecule. Clinical manifestations are diverse ranging from asymptomatic, to those who are carriers of the thalassemia, which may have mild symptoms, there also people who posses the trait, who may have severe symptoms which lead to death.
This paper focuses on the benefits of stem cell research in the medical and nursing field. New technology is always being created to help us understand the way the human body works, as well as ways to help us improve diseased states in the body. Our bodies have the ability to proliferate or regrow cells when damage is done to the cells. Take for example the skin, when an abrasion or puncture to the skin causes loss of our skin cells, the body has its own way of causing those cells to regrow. The liver, bone marrow, heart, brain, and muscle all have cells that are capable of differentiating into cells of that same type. These are called stem cells, and are a new medical tool that is helping regrow vital organs in our body to help us survive. Stem cells can come from adult cells, or the blastocyst of the embryo. The cells that come from these are undifferentiated, and can be specialized into certain cell types, making them available for many damaged tissues in the body. While using stem cells in the body is a main use, they are also being used to help doctors understand how disease processes start. By culturing these cells in the lab and watching them develop into muscles, nerve cells, or other tissues, researchers are able to see how diseases affect these cells and possibly discover ways to correct these diseases. While researchers have come very far in using stem cells, there are still many controversies to overcome when using these cells.
During a short break of solitude from studying, I explored and came across that the environment in which most African Americans reside in has a high occurrence of malaria virus. The malaria virus disease is contagious and when it contaminates someone with sickle cell traits, it cannot survive on the external part of the human body so therefore the individual doesn’t develop the deadly malaria virus. While looking further into our class textbook on Human Genetics 11th Edition by Ricki Lewis, and this issue of sickle-cell among the African Americans, I
Sickle-cell anemia is a genetic disorder that makes your body produce red blood cells that are abnormal in shape. This disease is also widely known as hemoglobin SS disease. Unlike normal red blood cells, sickle cells are rigid and tenacious. Due to their shape and rigidness, they can block blood flow. In turn, this could cause organ damage to the body. Sickle cells are also fragile and die very easily due to the fact sickle cells have a lifespan of twenty days instead of the normal one hundred and twenty days for normal red blood cells.This causes the body to have a lower blood cell count, hence the name anemia in sickle cell anemia.
Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
“The word 'leukemia' is a very frightening word. In many instances, it's a killer and it's something that you have to deal with in a very serious and determined way if you're going to beat it” - Kareem Abdul-Jabbar. Many people, including tons of children, fight leukemia every day trying to beat this vicious cancer. Without knowing how leukemia is exactly caused, it puts a damper on how to avoid it.
Sickle Cell Anemia is an inherited blood disorder that is extremely challenging to live with. Its symptoms are many, with the most prominent being severe pain that can become unbearable to the point where hospitalization is required. Because sickle cell is a genetic disorder, a person is born with it and it is usually permanent. Unfortunately, there are risks and complications associated with this disease. However there are various treatment options for a patient with sickle cell and also support to help people understand and cope with this challenging disease.
Sickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow as crescent shaped red blood cells. Unlike normal red blood cells, sickle shaped cells are unable to deliver much oxygen to other parts of the body due to the abnormal hemoglobin. Sickle cell’s are stiff and sticky and tend to clump together between blood vessels that can cause pain, damage to the organs, and infections. If a child inherits this disease they can be healthy throughout their life or need special care. “In the United States, SCD is most common among blacks and Hispanics. SCD affects about 1 in 500 black births and about 1 in 36,000 Hispanic births in this country. SCD is also common among people with family from Africa, the Caribbean, Greece, India, Italy, Malta, Sardinia, Saudi Arabia, Turkey or South or Central America (March of Dimes)”.
Some of our population may be more at risk then others due to the ethnic background. This diseases is more prominent in some races more than others and studies have shown where the numbers increase or decrease depending on the race. Decedents of Africa, India, the Mediterranean, South and Central America and the Caribbean have a higher percentage of diagnoses. Countries who are exposed to the malaria parasite have the higher number of Sickle Cell cases. The percentage of African Americans with sickle cell is about 1 in 500 and a percentage 1 in 1,000 to 1,400 in Hispanic Americans. People of Caucasian race are less likely to have the diseases because of the history of the d...
Thalassemia is a blood disorder transferred through families. It occurs when the body makes less hemoglobin than needed or an unusual form of hemoglobin. Hemoglobin is the protein in red blood cells that carry oxygen. The disorder makes an excessive amount of destruction of red blood cells. This eventually leads to anemia.