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Alterations in the hypothalamic pituitary system
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Hormones from hypothalamus are called regulatory hormones because they are molecules secreted into the blood to regulate the secretion of the anterior pituitary hormones. There are two groups of regulatory hormones. Group one is called releasing hormones which stimulate the production and secretion of the anterior pituitary hormones. Group two is called inhibiting hormones which deter the production and secretion of the anterior pituitary hormones. In this writing assignment we are focusing on releasing hormones. The hypothalamus consists of interconnecting neurons. Neurotransmitters, made up by a transmission of an electrical impulse and the secretion of a chemical substance, diffuses across the synapse of a presynaptic membrane on one neuron to the postsynaptic membrane of another neuron (Utiger, 2014). When a specific …show more content…
There are five hypothalamic hormones that stimulate the anterior pituitary and are called tropic hormones. The first is called Thyrotropin-releasing Hormone (TRH) which increases the secretion of thyroid-stimulating hormone (TSH) and stimulates the release of thyroid hormone from the thyroid gland. The second is Prolactin-releasing hormone (PRH) which increases the secretion of prolactin (PRL) and primarily regulates breast milk in women. Gonadotropin-releasing hormone (GnRH) is the third and it increases the secretion of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) which regulates the production and maturation of sperm and oocytes as well as hormonal synthesis by the gonads. The fourth hormone is called Corticotropin-releasing hormone (CRH) which increases the secretion of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and secrete corticosteroid hormones. An example of a corticosteroid hormone is cortisol. Lastly, the fifth hormone is the Growth hormone-releasing hormone (GHRH) which increases the secretion of growth hormone (GH) that stimulates cell growth throughout the
Briefly explain the process of neurotransmission. Neurotransmission starts with the neuron, the most important part of the central nervous system. A neuron contains a cell body, axon, and dendrites. When a neuron receives an electrical impulse, the impulse travels away from the cell body down the axon. The axon breaks off into axon terminals. At the axon terminals, the electrical impulse creates a neurotransmitter. The neurotransmitter is released into the synapse, a space between two neurons. If the neurotransmitter tries to stimulate a response of another neuron, it is an excitatory neurotransmitter. If the neurotransmitter does not stimulate a response of another neuron it is an inhibitory neurotransmitter. If a response is generated, the second neuron or postsynaptic neuron will receive an action potential at the site of the dendrite and the communication process will continue on. If a response is not generated, neurotransmitters left in the synapse will be absorbed by the first neuron or presynaptic neuron, a process known as reuptake. Neurotransmitters control our body functions, emotions, and
CAH is an autosomal recessive genetic disorder and males and females are affected in equal numbers. Chromosome 6 is where the group of genes lie that causes the most common forms of CAH. Adrenocorticotropic hormones (ACTH) are released by the anterior lobe in the pituitary gland. Its role is to act on cells of the adrenal cortex which then synthesizes corticosteroids and cortisol. However, those with CAH have insufficient amounts of the enzyme 21-hydroxylase, needed to convert 17-hydroxyprogesterone (17-OHP) into cortisol.
When something changes in the inner environment it sends information to the receptor. The receptor sends information to the control center and then the control center sends instructions to the effector once the information is received from the control center it proceeds to either oppose or increase the stimulus. This process is designed to repeatedly work at restoring or maintaining homeostasis.
Endocrinology is the study of the endocrine system and secretion of hormones with its different diseases. It is concerned with developmental events such as growth, differentiation, and the psychological or behavior of tissue function. Activities of hormones in sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction is involved .
The endocrine system is very dynamic and has ties to most, if not all of the other major systems of the body. It is responsible for production of hormones and the regulation of them as well. These hormones act as chemical messengers within the body. Through several differing mechanisms, they are able to trigger very specific responses in target cells or organs. This is what enables the endocrine system to guide growth, development, reproduction, and behavior, among many others as well.
The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes its way to the bloodstream until it reaches the thyroid where it is then signaled to activate T3 and T4 production [1]. This mechanism is controlled by a negative feedback loop meaning that when there is a sufficient amount of thyroid hormones in the blood stream, this will signal back to stop production of thyroid stimulating hormones. Complications occur when the thyroid hormones keep increasing even though there is already a sufficient amount of T3 and T4 in the blood stream. This process of over expression of thryroid hormones is known as hyperthyroidism. Hyperthyroidism is a general term that includes any disease that has a consequence of an overabundance of thyroid hormones. Hyperthyroidism is a general term but there are many variant diseases that are in the hyperthyroidism category. These diseases include diffuse toxic goiter, Basedow’s disease, thyrotoxicosis, Parry’s and Graves’ disease.
In order for neuron communication to occur, the post-synaptic neuron must have receptor sites for the neurotransmitters released by the pre-synaptic neuron. Also, these neurotransmitters, by binding on to the receptors, must bring about a change in the post-synaptic neuron, namely an EPSP (excitatory post-synaptic potential) or an IPSP (inhibitory post-synaptic potential), which may or may not lead to an action potential triggering in the post-synaptic neuron.
Carol Proth explains the development of the high androgens levels by the “increased release of LH [leutenizing hormone] in relation to FSH [follicle stimulating hormone] release, with a resu...
The endocrine system interacts with the nervous system to coordinate and integrate the activity of body cells. Unlike the nervous system, which sends signals chemically and electrically, the endocrine system sends signals only via chemical stimulants called hormones. These hormones are secreted by the cells into any extracellular fluids, which then travel through the blood to regulate any metabolic activity. Hormones have a diverse and widespread affect like controlling reproduction, growth, development, maintaining nutrient balance in the blood, regulating cellular metabolism and mobilizing the body defenses (Marieb et al 2013). In dealing with growth and development, the thyroid gland is always under consideration. The thyroid gland is the largest endocrine gland in the body that produces thyroid hormones that consist of two iodine-containing hormones called thyroxine (T4) and triiodothyroxine (T3) (Marieb et al 2013). Thyroid-stimulating hormones (TSH) are a tropic hormone that stimulates normal development and secretory activity of the thyroid gland. Thyrotropin-releasing hormones (TRH) are hypothalmic peptides that trigger the release of TSH from thyrotropic cells to different organs to help maintain the body’s metabolic state (Marieb et al 2013). Thyroid function has been known as a major contributor to the basal metabolic rate (O’Malley et al 2000). According to Longhi and Radetti, body composition and thyroid hormones are two components that are closely related. The hormones are involved in regulation of metabolism and thermogenesis, which plays a key role in lipid and glucose metabolism along with digestion of food and fat oxidation (Longhi et al 2013).
The anti-diuretic hormone, for example, is in charge of increasing kidney’s water absorption into the blood. The corticotropin-releasing hormone sends a message to the adrenal glands to release corticosteroids. Corticosteroids help regulate the metabolism and immune response. The gonadotropin-releasing hormone causes the anterior pituitary to release FSH, follicle stimulating hormone, and LH, luteinizing hormone, the two hormones that work together to guarantee normal functioning in the ovaries and testes. The growth hormone-releasing hormone makes the anterior pituitary release the growth hormone. Another hormone, the growth hormone-inhibiting hormone, stops this release.
This includes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from anterior pituitary gland which in turn stimulates ovary to secrete estrogen and progesterone hormone (Nelson, 2014). According to Mtawali et. al (1997), the changes of hormone will lead to changes in the female reproductive organ such as ovaries, uterus and cervix . Additionally, Mtawali et al. (1997) state the menstrual cycle can be divided into phases based on the changes that occur simultaneously in the ovary (involving the follicular and luteal phase) and the uterus (involving the proliferative, secretory and menstrual phase) as shown in figure 2. Based on figure 1, Mtawali et. al (1997) divide the menstrual into several phases, starting with follicular phase and proliferative phase, followed by luteal phase and secretory phase, menstrual phase (if there is no fertilization) and pregnancy (if fertilization
The thyroid gland is part of the endocrine system, and it is controlled by the pituitary which is known as the “master gland” of the endocrine system. The pituitary controls the thyroid by producing Thyroid Stimulating Hormone (TSH) which stimulates the production of thyroid hormones. . The thyroid gland secretes two main hormones: Thyroxine (T4) and Tri-Iodothyronine (T3). These hormones increase metabolic rate, heat production, oxygen consumption, appetite, growth hormone secretion, alertness and quicker reflexes. The thyroid gland is located in the anterior portion of the neck, beneath the Adam’s apple. It is divided in two lobes on either side of the windpipe: right lobe and left lobe. These lobes create what looks like a butterfly shape. The gland is essential to the contribution of maintaining the homeostasis of the body. It plays a role in monitoring the body’s expenditure of energy and running the body’s metabolism.
Swan, S.H., F. Liu, J.W. Overstreet, C. Brazil, and N.E. Skakkebaek. "Growth Hormones Fed to
Many men over 60 do not realize the importance HGH, or Human Growth Hormone, plays in their natural ability to restore and repair itself during times of rest. Human Growth Hormone is a naturally occurring hormone found in the human body. HGH is secreted from the pituitary gland at night, during slow wave sleep, and has many amazing health benefits.
The endocrine system is composed by a group of glands that secrete hormones for the secretion of a specific organ and the result of this cycle will contribute to of physiological and behavioral activities. The circulatory system makes a connection with the hormones secreted because it helps them to travel around the human body in a very short time. The endocrine glands that secrete the hormones that target specific hormones consist of the pituitary gland, thyroid gland, adrenal gland, pancreas, ovaries and testes. However, they are secondary organs part of the body system such as the kidney, liver, and heart. The kidney in particular secretes endocrine hormones such as renin and erythropoietin (EPO).