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Essaya About The Human Genome Project
Future use of the human genome project
Human genome project in society
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Jonas Salk once said that things such as the sun and his polio vaccine should belong “to the people”. These “things” also include the genes that the Human Genome Project and all its collaborators have isolated thus far. The Human Genome Project’s mission is to sequence and map all of the genes that make up the human genome in order to improve medical treatment for genetic diseases and quite possibly eradicate them. However, companies who are involved in the isolation of individual genes are lobbying for the right to patent said genes. These companies are trying to establish a monopoly on something that is as much a creation of nature as is the human body. This should not be allowed because it would impede medical research, make treatment harder to obtain as well as expensive, and violate the code of medical ethics.
Gene patenting has become a popular issue after the Supreme Court involved Myriad Genetics, a Utah based company, in a case where the company was sued for claiming to patent genes BRCA1 and BRCA2. These genes are both believed to be involved in increasing hereditary risk for breast and ovarian cancer. The case has caused a debate between the society if patenting genes is ethical and the correct use of science. The law states that genes are products of nature, but does that make them patent eligible? There are many pros and cons for patenting genes but recently the Supreme Court unanimously ruled that human genes cannot be patented. Justice Clarence Thomas unanimously decided that "Myriad [Genetics] did not create anything,” and that they “found an important and useful gene, but separating that gene from its surrounding genetic material is not an act of invention."(Adam Iptak, New York Times). DNA sequences are a part o...
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...sing it to be unaffordable by much of the population in the United States. Having no competitors in the market, and being the only source of a certain gene, the company would hike the costs for the majority of the people. Moreover, this would cause for a greater number of deaths and cause newer forms of diseases to become more prevalent. Overall, gene patenting is protecting property, rather than inventions, and as gene patenting monopolizes a particular gene, the cost increases to a point where much of the population is unable to afford treatment.
In conclusion, claiming possession of someone's genes is like taking an ownership of a part of their body. Patenting genes is unethical and causes for a significant amount of the population to be unable to afford medical treatment. Genes are part of nature, and not man-made inventions which should be protected.
In the late twentieth century, the field of biotechnology and genetic engineering has positioned itself to become one of the great technological revolutions of human history. Yet, things changed when Herber Boyer, a biochemist at the University of California, founded the company Genentech in 1976 to exploit the commercial potential of his research. Since then the field has exploded into a global amalgam of private research firms developing frivolous, profit-hungry products, such as square trees tailor-made for lumber, without any sort of government regulation.
In today’s modern age science is moving at a rapid pace; one of those scientific fields that has taken the largest leaps is that of genetics. When genetics first comes to mind, many of us think of it as a type of science fiction, or a mystical dream. Yet genetics is here, it is real, and has numerous ethical implications.
With the rise of new genetics neglecting the idea of human dignity, or what it means to be human, we will see a hierarchical system ruled by genetically modified people and the oppression that will follow.
The more we know about genetics and the building blocks of life the closer we get to being capable of cloning a human. The study of chromosomes and DNA strains has been going on for years. In 1990, the Unites States Government founded the Human Genome Project (HGP). This program was to research and study the estimated 80,000 human genes and determine the sequences of 3 billion DNA molecules. Knowing and being able to examine each sequence could change how humans respond to diseases, viruses, and toxins common to everyday life. With the technology of today the HGP expects to have a blueprint of all human DNA sequences by the spring of 2000. This accomplishment, even though not cloning, presents other new issues for individuals and society. For this reason the Ethical, Legal, and Social Implications (ELSI) was brought in to identify and address these issues. They operate to secure the individuals rights to those who contribute DNA samples for studies. The ELSI, being the biggest bioethics program, has to decide on important factors when an individual’s personal DNA is calculated. Such factors would include; who would have access to the information, who controls and protects the information and when to use it? Along with these concerns, the ESLI tries to prepare for the estimated impacts that genetic advances could be responsible for in the near future. The availability of such information is becoming to broad and one needs to be concerned where society is going with it.
“If you patent a discovery which is unique, say a human gene or even just one particular function of a human gene, then you are actually creating a monopoly, and that's not the purpose of the world of patents” (John Sulston). The articles “Patenting Life” by Michael Crichton, and “Decoding The Use of Gene Patents” written by John E. Calfee talk about the patenting of genes. Crichton and Calfee both discuss the different views on gene patenting. Crichtons position is against gene patents, while Calfee feels gene patents are beneficiary. Furthermore, the authors disagree with their views of gene patents. They have different views about the cost of the gene patent tests, the privacy of a person’s genes, and research of gene patenting.
In September 14, 1990, an operation, which is called gene therapy, was performed successfully at the National Institutes of Health in the United States. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes to target cells and replaces defective genes in order to cure the diseases which cannot be cured by traditional medicines. Although gene therapy gives someone who is born with a genetic disease or who suffers cancer a permanent chance of being cured, it is high-risk and sometimes unethical because the failure rate is extremely high and issues like how “good” and “bad” uses of gene therapy can be distinguished still haven’t been answered satisfactorily.
This argument has been brought forward to multiple courts. First this case was brought up in the United States District Court for the Southern District of New York, which decided it was not okay for the human genes to be able to be patented. The case was appealed and presented in the Federal Circuit Court of Appeals, which went against the decisions of the District Courts and said it was in fact okay to be able to patent the human genes sequence. Finally, the case was appealed again and presented in the Supreme Court.
The Human Genome Project is the largest scientific endeavor undertaken since the Manhattan Project, and, as with the Manhattan Project, the completion of the Human Genome Project has brought to surface many moral and ethical issues concerning the use of the knowledge gained from the project. Although genetic tests for certain diseases have been available for 15 years (Ridley, 1999), the completion of the Human Genome Project will certainly lead to an exponential increase in the number of genetic tests available. Therefore, before genetic testing becomes a routine part of a visit to a doctor's office, the two main questions at the heart of the controversy surrounding genetic testing must be addressed: When should genetic testing be used? And who should have access to the results of genetic tests? As I intend to show, genetic tests should only be used for treatable diseases, and individuals should have the freedom to decide who has access to their test results.
The age of genetic technology has arrived. Thanks to genetic technological advancements, medical practitioners, with the help of genetic profiling, will be able to better diagnose patients and design individual tailored treatments; doctors will be able to discern which medications and treatments will be most beneficial and produce the fewest adverse side effects. Rationally designed vaccines have been created to provide optimal protection against infections. Food scientists have hopes of genetically altering crops to increase food production, and therefore mitigate global hunger. Law enforcement officers find that their job is made easier through the advancement of forensics; forensics is yet another contribution of genetic technology. Doctors have the ability to identify “high-risk” babies before they are born, which enables them to be better prepared in the delivery room. Additionally, oncologists are able to improve survival rates of cancer patients by administering genetically engineered changes in malignant tumors; these changes result in an increased immune response by the individual. With more than fifty years of research, and billions of dollars, scientists have uncovered methods to improve and prolong human life and the possibilities offered by gene therapy and genetic technology are increasing daily.
Genes are, basically, the blueprints of our body which are passed down from generation to generation. Through the exploration of these inherited materials, scientists have ventured into the recent, and rather controversial, field of genetic engineering. It is described as the "artificial modification of the genetic code of a living organism", and involves the "manipulation and alteration of inborn characteristics" by humans (Lanza). Like many other issues, genetic engineering has sparked a heated debate. Some people believe that it has the potential to become the new "miracle tool" of medicine. To others, this new technology borders on the realm of immorality, and is an omen of the danger to come, and are firmly convinced that this human intervention into nature is unethical, and will bring about the destruction of mankind (Lanza).
Human Genetic Engineering: Designing the Future As the rate of advancements in technology and science continue to grow, ideas that were once viewed as science fiction are now becoming reality. As we collectively advance as a society, ethical dilemmas arise pertaining to scientific advancement, specifically concerning the controversial topic of genetic engineering in humans.
The controversy of these issues stems from the immense potential in genetic sciences for both positive use and harmful misuse. Though the questions and fears of critics reflect the wisdom of caution, the potentially unlimited benefits mandate that we pursue these technologies.
In an article titled “The Ethical Implications of Gene Therapy” the group of advisers on Ethical Implications of Biotechnology of the European commission states issues and rules that should be abided by, along with beliefs on the direction of biotechnology. At its present stage, biotechnology focuses on serious diseases which are incurable at the moment, however through this research treatment for these diseases could be found. The group of advisers feel that there should be levels at which research should focus on, instead of jumping into it all at once. Basic research should be carried out prior to clinical trials, and then move on to biotechnology. This can be done by supporting research actions, organizing training and exchange programs or any other appropriate means. Gene therapy protocols require that ethical evaluation consists of processes assuring quality, transparency and efficiency without delays of treatment to the patients who need it. This is crucial because an inefficient, poor quality treatment could cost someone their life. The group also feels that gene therapy research should be restricted to serious diseases for which there is not a current treatment. Expanding research to other things could be done if a medical evaluation calls for it. Equal access should be assured to all researchers within the European Union, thus sharing information and helping to improve orphan drugs. This could also save time and money. In order to insure the public of what is going on, conclusions of evaluations should regularly be published to encourage public debate. The public is not usually informed much about genetic therapy and many people have the wrong idea about it. Should reports be published more often, there will be less public confusion and ridicule.
Scientists and the general population favor genetic engineering because of the effects it has for the future generation; the advanced technology has helped our society to freely perform any improvements. Genetic engineering is currently an effective yet dangerous way to make this statement tangible. Though it may sound easy and harmless to change one’s genetic code, the conflicts do not only involve the scientific possibilities but also the human morals and ethics. When the scientists first used mice to practice this experiment, they “improved learning and memory” but showed an “increased sensitivity to pain.” The experiment has proven that while the result are favorable, there is a low percentage of success rate. Therefore, scientists have concluded that the resources they currently own will not allow an approval from the society to continually code new genes. While coding a new set of genes for people may be a benefitting idea, some people oppose this idea.
Advancements in science and medicine are usually accompanied with a myriad of ethical and moral implications. The fairly recent advancement in genetics called gene therapy is no exception to the baggage of polarizing views that come with new technology. Gene therapy is an extremely hot topic in both the science world and everyday life. New technology, discoveries, and breakthroughs are rapidly occurring in the field every day. The topic of gene therapy in humans is one that is highly debated due to the ethical implications connected to the science. Both sides of the debate have various reasons for their position, but the main factors come down to the ethics of changing someone’s genome and the consequences that accompany the altercations. The two types of gene therapy, somatic and germ-line are seen in different lights. There is more debate over germ-line therapy because the alterations have more consequences than somatic gene therapy. There are many moral and ethical decisions that need to be considered before gene therapy can be widely accepted. Do we have the right to change a person’s genetics, especially before they are born? Do we know enough to confidently insert or delete genes without detrimental consequences down the road? If we have the ability to help people who have disabilities or diseases, is it ethical to withhold and not treat the patient? I believe human gene therapy is a good and useful tool for medicine and needs to be developed because it posses the ability to help and cure people from ailments that degrade their quality of life.