Gcf Diet Theory

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The opioid excess theory is one of the main theories surrounding the GFCF diet as an intervention for autism. The theory states that children with ASD have lower levels of enzyme activity and that this causes fewer gluten or casein peptides from being broken down into amino acids, these peptides then leak into the bloodstream and bind to opioid neuro-receptors, which then causes behaviors associated with ASD. However, there are mixed results from studies evaluating whether this is actually the case, (Mulloy et al). There have been a variety of different studies on the effect of a gluten and casein free diet on autism. Likewise, there is a large variety in the results of these studies. Some studies have looked at urinary peptides levels …show more content…

In this study, ten children were put on the diet, while ten remained controls(Knivsberg et al), the study showed a statistically significant reduction in mean number of autistic traits, as well a greater increase of linguistic age compared to the control group, and the diet group had a decrease in motor problems, which was significant compared to the increase seen in the control group. (Millward et al.) Urinary peptides were not measured after implementation of the diet. Another study, Cade et al, evaluated 70 children with autism and compared their urinary peptide levels to non-autistic controls, they were on average significantly higher (Cade et al). Cade et al’s study also noted significant improvement in social isolation, eye contact, speech, learning skills, hyperactivity, stereotypical activity, panic attacks, and self-mutilation in 81% of the children, after three months to a year on the diet. (Cade et al.) Five of the children who had not improved on the diet had their UPL levels retested and they were shown to still be elevated (Cade et al), despite dietary intervention. However, once again the children who had reported improvement on the diet did not have UPL’s retested, so it is possible that they continued to have elevated UPL’s. Despite the findings of these two studies, a third study, by Elder et al’s double blind study tested UPL’s at multiple points during the trials and found no significant differences in UPL’s (Elder et al.). This study also saw no significant differences within group data evaluating behaviors on the CARS or ECOS

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