Fulcrum Therapeutics Essay

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Fulcrum Therapeutics • Overview & Details of the business: URL, location, number of employees, date founded. -Founded in 2016, Fulcrum Therapeutics is a privately owned biotechnological industry that specializes in Gene Regulation, Neuromuscular Diseases, Rare Genetic Diseases, and Cardiovascular Diseases treatment research. Fulcrum’s main focus is to define the molecular interactions of the small molecules with the target proteins. It is based in One Kendall Square Building 700 Cambridge, MA 02139 United States and employs 11-50 personnel. Some of its URL are; -www.fulcrumtx.com/ - https://www.linkedin.com/company/fulcrum-therapeutics -https://twitter.com/fulcrumtx • Details of services: what services do they …show more content…

Their motivation is to create a positive change in the patient and their families lives by developing small molecules that modulate the on and of control of mechanism that regulate genes. The two most common disease that their program is focused on are, Facioscapulohumeral muscular dystrophy (FSHD), and Fragile X syndrome (FXS). FSHD for example, is a progressive myopathic disease that affects humans of all ages caused by disrupted genetic and epigenetic regulation of a macrosatellite repeat (Himeda, Jones, & Jones, 2015). It is slowly progressive muscle disorder that affects 1 in every 20,000 individuals. Fulcrum is developing a small molecule that stabilizes the disease process through the restoration of the repressive DUX4 gene regulation as well as advising patient on the kind of step the should take to mitigate the complications from FSHD. At the moment, there are no known treatments that will reverse the weakening of muscle and wasting in FSHD (Fulcrum Therapeutics, 2017). For each of its two lead programs, Fulcrum is gratified to be working closely with patient groups who are partners in our search to better understand the disorders and to develop breakthrough medicines. For every program the company starts, we regard partnership with patient groups as essential to our …show more content…

The collaboration will incorporate the Horizon’s world-leading CRISPR-based screening technology to identify novel targets for regulating gene expression and subsequent manipulation (Horizon, 2016). • Financial: any financial details available? -Third Rock Ventures was the initial financier and founder of the Fulcrum Therapeutics with an out-front establishment amount of 55 million series A funding. In May 10th, 2017 Fulcrum announced that it had secured some additional series A funding from the (Google Venture) GV to facilitate the continued effort in the Fragile X syndrome (FXS). • Future plans: any indications of future plans for the business? -Fulcrum Therapeutics projects to be among the strongest biotech industries in term of technology, partnerships, venture backers and posting a competitive market position as their name as already appeared in the Fierce 15 biotechnology companies. “Fierce 15” are the top15 ranked biotechnology companies championing innovation and creativity by the biotech industry's daily monitor

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