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Fibrodysplasia ossificans progressiva essay
Fibrodysplasia ossificans progressiva essay
Fibrodysplasia ossificans progressiva essay
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History
The history of the disease can be traced over two hundred and eighty-one years ago to the first medical record of fibrodysplasia ossificans progressiva characteristics mentioned. As stated in Kaplan research in Fibrodysplasia ossificans progressiva: an historical perspective, the disorder was first clearly described in a letter to The Royal Society of Medicine dated 14 April 1736, by London physician John Freke (Kaplan, 2005, pp. 179). In keeping with Kaplan’s research, John Freke reported a healthy teenage boy came into the hospital with large swellings on his back that began around the age of three. Furthermore, the teenage boy was noted as having swellings that arose from the vertebrae of his neck to his sacrum, and the entire rib cage appeared to be joining together in all parts of his back. Over the next hundred years, several similar medical cases were reported from all
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Physicians were baffled by the disease, and needed to establish better knowledge, prevention, and treatment for their patients.
Physical Characteristics The first physical characteristics of fibrodysplasia ossificans progressiva at birth are typically malformations of the great toe or fingers. The example in Figure 1 demonstrates the classic FOP characteristic hallux valgus, which is the inward turning of the great toes. It is stated by National Organization for Rare Disorders (NORD), these abnormalities in the great toe will be shorten, a malformed distal first metatarsal, and missing or abnormal interphalangeal joint. Furthermore, NORD explained there are pre-osseous soft tissue swellings that begin in early childhood with FOP patients. These flare-ups and swellings as seen above in Figure
Also evident are molluscoid pseudotumors (fleshy lesions associated with scars) frequently found over pressure points (e.g. elbows) and subcutaneous spheroids, which are commonly mobile and palpable on the forearms and shins. Complications of joint hypermobility include sprains, dislocation are common in the shoulder, patella and temporomandibular joints Muscle hypotonia and slower gross motor development also can occur It is inherited in an autosomal dominant manner (Clarke, D., Skrocki-Czerpak, K., Neumann-Potash, L.). In the Hypermobile type of EDS, the joints of the body experience Hypermobility, which is the dominant clinical manifestation. General joint hypermobility affects large (elbows, knees) and small (fingers and toes) joints. Skin is hyperextensible, smooth/velvety, and bruising occurs easily as well.
Fibrodysplasia ossificans progressiva also known as FOP is a one of the rarest, most disabling genetic bone conditions known to medicine. FOP causes muscles, tendons, ligaments, and other connective tissues to turn in to bone. Movement becomes limited in the affected areas of the body. People with FOP typically have malformed toes at birth, meaning the big toe is typically shorter than normal and abnormally turned outward in a position called a valgus deviation. Symptoms of FOP start to show up in early childhood. Most people with FOP develop painful tumor-like swellings also known as fibrous nodules. The fibrous nodules are visible on the neck, shoulders, and back.
Just 25 miles south of San Francisco, on the southern end of Crystal Springs Lake, lies Fioli, a spectacular historic Georgian mansion and estate surrounded by 654 acres of park land, 16 of which are designed as formal gardens adjacent to the home. It offers professionally guided or self-guided tours to the public 6 days a week and makes a wonderful day trip from San Francisco or Santa Cruz for anyone interested in history, architecture or gardening.
Osgood-Schlatter Disease or syndrome (OSD) is an irritation of the patellar ligament at the tibial tuberosity (Dhar). Osgood-Schlatter Disease is claimed by some to not actually be a disease (Sims). But is rather a collection of symptoms that involve the tibial tubercle epiphysis (Sims). Osgood-Schlatter Disease affects as many as 1 in 5 adolescent athletes (Diseases and Conditions: Osgood-Schlatter Disease). Some other common names for this disease are Osteochondrosis, Tibial Aponphysitis, Tibial Tubercle Apophyseal Traction Injury, Morbus Osgood-
Osteogenesis Imperfecta (OI), also called fragile bone ailment or Lobstein disorder, is an inherent bone issue portrayed by weak bones that are inclined to break effortlessly with practically zero cause. A arrangement of various sorts of OI is regularly used to depict how seriously a man with OI is affected.OI is brought on by hereditary deformities that influence the body's capacity to make solid bones. In predominant established OI, a man has too little sort I collagen or a low quality of sort I collagen because of a transformation in one of the sort I collagen qualities which makes the bones
James Parkinson. It’s not certain how long the disease has existed but its probably been around
to the disease. Many people who knew nothing about medicine used this as an opportunity to get
The first historical account of muscular dystrophy was identified by Sir Charles Bell in 1830. He wrote about a disease that caused weakness in boys that progressively got worse. In 1836 another scientist whose name is unknown reported about two brothers who developed muscle damage, generalized weakness. Also damaged muscle was replaced with fat and connective tissue. At the time the symptoms were thought to point to tuberculosis. During the 1850s reports of boys with progressive muscle weakness became more and more common. There were also reports of these boys losing the ability to walk and dying at an early age. In the next decade French neurologist Guillaume Duchenne gave and in depth account of 13 boys who had the most common ...
The syndrome is caused because of Genetic mutation that replaces connective tissues (muscles) with bones when someone gets injured instead of getting cured. This results in a new skeletal structure. Unfortunately this syndrome does not have any cure and the patients are advised to always be careful and not to fall or have any kind of traumas. They can’t engage in any sports in order to prevent any injuries. Surgery for removal of extra bones is not an option because removal of bones will lead to ingrowth of more bones. From previous cases it is seen that most of the patients suffering from this condition do not live more than 40 years and they die of respiratory
While scientists worked to find a cure, policyholders that conducted legislative procedures were defining and enacting the problem; policies were designed to isolate sick patients as prevention of the further spread of the disease.
Due to the lack of an ability to find a cure, Doctors as a whole saw that the only way to solve this problem afflicting society was to send the afflicted away from the sight of the
Subsequently, these disorders are not revealed to the healthcare provider which will transcend to delay of treatment, reduction in quality of life,
These treatments did not work, and over time, doctors began refusing to see patients because they wanted to stay healthy as well. (Trueman, Cures for the Black Death).
Scoliosis is a progressive disease. In its early stages a mild rotation and rib deformity is detected. As it progresses more vertebrae rotate, causing the ribs to crowd together on one side of the chest and to spread apart on the opposite side. The disease is usually first identified in persons 10 to 17 years old. Most cases occur in girls and become apparent during the rapid growth phase of puberty. Conditions also include shoulder unleveling, waistline discrepancies, acute headaches, shortness of breath, rib hump, chronic fatigue, and mood swings.
The secret to providing the right treatment for potentially serious, health conditions is early diagnosis. Normally, the sooner patients