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Mild cushing's syndrome
Mild cushing's syndrome
Mild cushing's syndrome
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Recommended: Mild cushing's syndrome
After the removal of the tumour there is enough ACTH getting produced by the pituitary gland which means the adrenal glands isn’t producing enough cortisol
Injection or oral intake of synthetic cortisol is the only treatment involved in Cushing’s disease
Medicine called: Glucocorticoid medication
This hormone treatment can take as long as months or even years until the patient’s cortisol can return back to normal
In serious cases the pituitary gland is removed with the tumour meaning the patient will need lifelong hormone replacement therapy
Necessity of Hormone (Synthetic cortisol) Therapy for Cushing’s Disease
After the tumour has been removed, hormone theory involving cortisol injection is needed to ac as the pituitary temporarily and somethings permanently as the pituitary gland stops
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The hormone treatments either taken orally with a tablet or a synthetic cortisol injection into the shoulder
The effects on the body without cortisol:
Weakens
Fatigue
Insomnia
Anxiety
Nausea, diarrhoea, vomiting
Over stressing
Heart palpitations
These symptoms causes an unbalance of homeostasis and are not normal
By doing hormone treatment, it substitutes for cortisol that is currently or premanetly not being made thus preventing all the above symptoms
This ensures that blood sugar levels are right and that a patient can cope and deal with stress
Side Effects
Cortisol flared caused by injection
Pain in joints is usually due to the solution crystallising
This pain can last up to 1-2 days
Injection site can:
Change skin colour
Skin indentation
Infection in joint
Ununsal menstrual patterns
Suppressed immune systen
Increased blood pressure
Bone loss
Increased fat deposit
Risks
A huge risk is that the body starts relying on the external cortisol from hormone treatments which can causing the adrenal gland to stop making cortisol
Lethal or permanent damage to the pituitary gland or nervous system can occur when the tumour is being surgical
Tumors or Lesions to the Hypothalamus Patient The Hypothalamus is a small area near the base of the brain just ventral to the thalamus. It has widespread connections with the rest of the forebrain and the midbrain. Partly through nerves and partly through hypothalamic hormones, the hypothalamus conveys messages to the pituitary gland, altering its release of hormones (Kalat, 2003). Any type of damage to a hypothalamic nucleus, such as tumors or lesions, may lead to abnormalities in one or more motivated behaviors, such as feeding, drinking, temperature regulation, sexual behavior, fighting, or activity level.
The hypothalamus releases corticotrophin (CHR), which is a chemical messenger. CHR stimulates the pituitary gland to release adrenal corticotrophin (ACTH). ACTH, which is released into the blood, then signals the adrenal gland. When the adrenal gland receives ACTH, it is the chemical signal for cortisol production. In a normal system, cortisol (an anti-inflammatory) production would stop after being released, but if there is a break down in the process, cortisol production continues, leading to Cushing’s disease....
The purpose of a homeostatic system is to maintain steady/stable internal environment at a set point. Glucose is used as a major energy source by most cells in the human body. Cells break down glucose in order to produce ATP (energy), to carry out their cellular processes. Blood glucose concentration is maintained between 3.9-5.6 mmol/L-1. The reason behind this range is due to the fact that people of different ages and genders require different amounts of glucose in their blood to carry out different metabolic processes. For example, a growing teenage boy would require a higher blood glucose concentration in comparison to a middle aged women. Blood glucose concentration must be maintained between this set point range because anything above or below this can cause severe problems. If blood glucose concentration becomes too low the tissues in the body that solely rely on glucose as an energy source are greatly affected, as they need a constant supply of glucose in order to function adequately. These
Although the flow chart is straight forward and easy to follow, nurses often use nursing wisdom, which is based on their knowledge and experience (McGonigle & Mastrian, 2012). For example, rather than giving orange juice or one tube of glucose gel and rechecking a patient’s blood glucose in 15 minutes, nurses may wait for a breakfast tray to arrive and recheck a patient’s blood glucose after breakfast. Possible risks include a patient not eating his or her breakfast and their blood sugar continuing to drop. Possible benefits are a patient eats his or her breakfast and his or her blood sugar returns to normal. However, there are applications in the computer where a diabetic educator is able to view when a patient had a low blood sugar and it was not rechecked in a timely manner to ensure that the blood glucose returned to normal. Managers are often being talked to by diabetic educators, because nursing staff at times decide to use their own judgment when treating low blood sugars rather than following the hospital protocol and then nurses are forced to explain their decisions. Thus, the importance of documenting and ensuring a patient’s blood glucose has returned to normal, even though the flow chart was not implemented is often emphasized.
Cushing syndrome was named after Harvey Cushing in 1912. “Harvey Cushing first described the symptom complex of obesity, diabetes, hirsutism, and adrenal hyperplasia. He gave a vivid description of his first patient who was 23 years old and presented with the “most extraordinary appearance”” (“Osler’s phenomenon”: misdiagnosing Cushing’s syndrome; Postgraduate Medical Journal; October 2003). Although, Sir William Osier was the first to describe the symptoms of Cushing’s, but diagnosed his patient with myxoedema by mistake. Unfortunately many people were misdiagnosed, therefore, leading to mortality. In 1933, Cushing performed his first neurosurgery on his patient, which did not gain acceptance until much later. “Adrenal surgery was for many years the treatment of hypercorticism but prior to the availability of glucocorticosteroids substitution an extremely perilous undertaking” (Cushing’s syndrome: Historical Aspects, Lindholm J., October 2000).
... certain adrenal cortical steroids are powerful inhibitors of inflammation, toxic side effects limit their usefulness. Similarly, drugs that inhibit proliferation of cells in the inflammatory masses have potentially severe side effects. Drugs that inhibit undesirable inflammation may also inhibit desired inflammatory responses.
Anabolic steroids, technically known as anabolic-androgenic steroids, are drugs that are related to the cyclic steroid ring system and have similar effects to testosterone in the body. They increase protein within cells, especially in skeletal muscles. They address the development and maintenance of masculine characteristics such as the growth of the vocal cords, testicles and body hair. Anabolic steroids were first made in the 1930s, and are now used therapeutically in medicine to stimulate bone growth and appetite, induce male puberty and treat chronic wasting conditions; such as cancer and AIDS. The American College of Sports Medicine acknowledges that AAS, in the presence of adequate diet, can contribute to increases in body weight, often as lean mass increases and that the gains in muscular strength achieved through high-intensity exercise and proper diet can be additionally increased by the use of AAS in some individuals.
Although steroids have many negative effects, they have many needed medical purposes. Androgens have many legitimate medical uses, such as the use for treatment of hypogonadal men to compensate for the lack of endogenous production. Anabolic steroids are also helpful for the treatment of certain adolescent diseases, some types of anemias, and for a relatively rare form of edema. Other clinical uses focus on the tissue building and anti-catabolic effects, such as in the treatment of burn victims, AIDS, or HIV positive patients, or patients malnourished from disease or old age (Bellino 1).
There are many different types of treatment but the main ones include surgery, chemotherapy, and radiation. However, sometimes children’s immunes systems rid themselves of neuroblastoma before anything needs to be done. Therefore, doctors prefer to give the tumor a little bit of time, depending on the seriousness, before taking unnecessary actions. Surgery is often done for many types of cancer and can be a very successful treatment. Despite this fact, “ . . . most neuroblastoma is not found until after the cancer has spread. In that situation, the doctor removes as much of the tumor as possible during surgery” ("Neuroblastoma - Childhood: Treatment Options"). If the tumor cannot be completely removed by surgery, sometimes doctors will advise chemotherapy or radiation to eliminate the rest. Chemotherapy can also be effective but can have some unwanted side effects. “Chemotherapy is the use of drugs to destroy cancer cells, usually by stopping the cancer cells’ ability to grow and divide . . . The side effects of chemotherapy depend on the individual and the dose used, but they can include fatigue, risk of infection, nausea and vomiting, hair loss, loss of appetite, and diarrhea” ("Neuroblastoma - Childhood: Treatment Options"). The doctor and parents may believe that the potential side effects could be too dangerous for a young child to endure. Another treatment option includes the use of radioactive energy. It is explained, “Radiation therapy is the use of high-energy x-rays or other particles to destroy cancer cells . . . radiation therapy can sometimes cause problems with the normal growth and development of a child’s brain and the ovaries (in girls) or testicles (in boys) . . .” ("Neuroblastoma - Childhood: Treatment Options"). Alike to chemotherapy, the side effects may be too severe for young children. The possibility of stunting a child’s brain growth can seem to harsh.
Cushing’s syndrome is a disorder resulting from a prolonged exposure to high levels of glucocorticoids. It is subdivided into two groups based on the cause of the hypercortisolism, either adrenocorticotropic (ACTH) -dependent or –independent.1
Treatment is pending on the severity of the cancer. Options for treatment are: surgery, thyroid hormone treatment, radioactive iodine therapy, external radiation therapy and chemotherapy. Depending on the size of the nodule, age and if the cancer has spread, patients are more likely to have more than one treatment. Each treatment plan is developed to meet that patient’s needs. (Thyroid Cancer, 2012)
Journal of Diabetes Science and Technology: Self-Monitoring of Blood Glucose: Practical Aspects. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864180/. Taylor, C., LeMone, P., Lillis, C., & Lynn, P. (2008). Fundamentals of nursing: the art and science of nursing care (6th ed.). Philadelphia, PA, Lippincott Williams & Wilkins, a Wolter Kluwer business.
...al Hypogonadism and Androgen Replacement Therapy: An Overview." Medscape. Urol Nurse, 2006. Web. 20 Nov. 2013. .
Oxytocin and ADH are both transported to the posterior pituitary gland to be stored and release later when they are needed.
One of the best meditation benefits is reducing the well-known stress hormone Cortisol. In fact, Cortisol does significant damage to our bodies. With today's fast-paced society, it is common for many people to have too much cortisol surging through their bodies. High levels of cortisol have been found to increase heart attacks, increase undesirable cholesterol, lower bone density, increase blood pressure, cause hyperglycemia, suppress healthy thyroid and lower immunity