Biology Cover Letter Sample

I am writing to express my keen interest in the position of Staff Scientist in the Endocrine Oncology Branch advertised on Indeed career website. I believe my twelve years of academic research expertise in the fields of cancer biology and oncology drug discovery makes me uniquely suitable for the position.
I obtained my Ph.D. in micro/molecular biology from the Nickerson laboratory at the University of Nebraska-Lincoln, where I investigated pathogenic fungi Candida albicans morphogenesis, and host-fungal interactions. I discovered that upon being phagocytized by macrophages, C. albicans pierce the phagolysosome by inducing hyphae by up-regulating cAMP/PKA pathway. But, before dying, macrophages induce the expression of IL-6, IL-1beta, TNF-alpha, and IL-10, which help developing specific Th cells. While in the acidic conditions such as phagolysosome, C. albicans alters the production of quorum sensing molecules to reduce the acidic microenvironment as a survival strategy.

Specifically, I identified that a point mutation in Mps3 causes the formation of abnormal shaped nuclei that is rescued by altering membrane fluidity. Mps3’s role in membrane fluidity, spindle pole duplication, and macromolecule (spindle pole body) insertion into the nuclear envelope were investigated. This finding was regarded as a research breakthrough by Eurekalert (AAAS). In another project, three lysine residues were mapped by mutation analyses that are acetylated by nuclear acetyl transferase (Eco1). The acetylation of Mps3 is critical for nuclear organization such as sister chromatid cohesion, telomere tethering, and gene