Alzheimer's disease is the most common form of dementia, and this terminal, progressive brain disorder has no known cause or cure. Its greatest known risk factor is increasing age which is why is it is infamous for developing in the elderly, typically in ages 65 or over, however for the 5%(1) that develop Alzheimer’s in their 40s or 50s it is known as early Alzheimer’s. Because Alzheimer’s worsens over time, those with it tend to struggle with completing daily tasks especially elderly people. Given that there is no cure for Alzheimer’s, the treatments available slow the worsening of dementia symptoms and improve quality of life for those with Alzheimer’s and their caregivers. It is not known what causes Alzheimer's, however, those with Alzheimer's have been found to have abnormal amounts of protein (amyloid plaques) and fibres.(The amyloid plaques and fibres are found in regions of the brain where problem solving and thinking take place e.g The cerebrum.) Due to the unusual amounts of amyloid plaques and fibres, it reduces the effectiveness of healthy neurons and eventually, destroying them. Alzheimer's disease is the sixth leading cause of death in the United States(1). Alzheimer's has no cure or any way of preventing it from occurring. Life expectancy continues to grow due to improvements in medicine, and so Alzheimer's Disease will continue to be a problem in the elderly. Looking at figure 1(3), it shows that from the year 2000, cases of Alzheimer's disease are estimated to double by the year 2040, which is most likely due to the fact that medicine will continue to improve. Despite not knowing the causes of Alzheimer’s, there have been studies(2 and 7) showing that high cholesterol or high blood pressure can increase the risk... ... middle of paper ... ...d up in lysosomes of the amyloid precursor protein (APP). Once broken, in an improper process, into toxic peptides which are associated with Alzheimer's Disease, researchers suggest they are perhaps a reason for the development of Alzheimer’s disease. Within weeks of using gene therapy to increase the activity of the NEU1 enzyme, it was found that plaque began to decline. The regions in which the researchers saw a decline in plaque was in the hippocampus. The hippocampus is where memory and learning take place in mice. To insert the gene scientists used a modified cold virus as the vector to implant the NEU1 gene into the brain cells of the mouse. This suggested that the lack of this gene meant that it could lead to Alzheimer’s disease, however the gene could also be used to slow the worsening of Alzheimer’s disease or possibly even “ reverse “ the disease process.
The sixth leading cause of death in the United States, Alzheimer’s disease afflicts approximately 5.2 million persons age 65 and over (Alzheimer's Association, 2012). Rapid growth of the older population as the Baby Boomer generation ages will cause unprecedented increases in the number of individuals with Alzheimer’s. It is estimated that by 2025 the number of Wisconsin residents with Alzheimer’s age 65 and older will increase by 30% to a projected total of 127,000 (Alzheimer's Association, 2012).
Think about it, an average teen in this world has just been diagnosed with a type of incurable dementia which will forever change his or her life. Frontotemporal dementia (FTD) is one of the less common forms of dementia. It is when the nerve cells in the frontal lobe die and over time the brain tissue shrinks. Frontotemporal dementia is mostly found in people who are in their teens or twenties. It can affect young people in a very negative way. They start to get aggressive and as the disease gets worse they lose friends and have a difficult time in school and understanding things. Frontotemporal dementia is a rare disease that is on the rise and affects the people of the younger generation.
Although Alzheimer’s disease appears to be the most common cause of dementia, “more than 50 conditions are associated with dementia, including degenerative ...
Clinically, Alzheimer’s disease is characterized by the accumulation of beta-amyloid plaque between living neurons in the brain (Sabbagh, 2008). This results in an excessive calcium influx inside the neurons and the breakdown of a protein called tau. Normally, the rol...
Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.
Dementia is a significant health issue in Australia (Australian Institute of Health and Welfare 2012) (AIHW 2012). Whilst Dementia primarily affects older members of the community, it can also affect young people and has a significant influence on overall health and quality of life (AIHW 2012). The type of Dementia is a determinant in the severity and development of symptoms in individuals (Department of Health 2013) (DoH, 2013). The gradual, progressive and irreversible nature of Dementia has a considerable social and physical impact not only on the individual, but also on family and friends.
This paper is on dementia, a late-life disorder, as it pertains to the geriatric population. “It is estimated that 24.3 million people around the world have dementia and that, with an estimated 4.6 million new cases every year, we can expect about 43 million people and their families to have to handle the challenge of dementia by 2020.” (McNamera, 2011) I will cover three relevant points concerning this disorder that cause changes in the brain.
Alzheimer’s is a terrible disease, the diagnosis of which marks a long and painful journey through neurofibrillary degeneration. Unfortunately, there are so many factors that lead to and expedite the disease that synthesizing a cure is no simple task by any means. Whether the cause of the disease is hyperphosphorylation of tau or beta-amyloid plaques, current medical technology can only delay the symptoms. Hopefully the future of medical research will yield a method for reversing the progression of the neurological degeneration because far too many victims and their friends and family are forced to embark on the long and painful journey of Alzheimer’s.
In the field of Psychology you can find an abundance of mental disorders that can have an affect on people all throughout the world. Out of all the mental disorders that can be found around the world, some of them are more well-known and more widespread than others. The following disorders could be described as being well-known and widespread disorders: depression, bi-polar disorder, Alzheimer's, and OCD, which could also be called Obsessive Compulsive Disorder. All of these mental disorders can be very dangerous and possibly deadly if people don't receive the proper care in order to be able to contain these disorders. Out of these very dangerous and possibly deadly disorders, I believe that Alzheimer's is the most interesting disorder. I think that Alzheimer's is the most interesting disorder, because I think we have the least about of knowledge of the Alzheimer's disorder. As a society we still to this day don't have a cure that totally stops this disorder.
Alzheimer’s disease is one of the most prevalent diseases in America and in the world at this point in time and the number of cases is only increasing. Symptoms of Alzheimer’s might include a decline in mental capacity, confusion, and forgetting how to do simple tasks. The disease in not limited to the older generation but is far more prevalent. There is no existing cure for Alzheimer’s and only a few medications that can mildly treat the disease but they vary from patient to patient and are not very affective. Many people are now trying to focus on preventing the disease in its early stages. Some ways in which people do this is by pairing a healthy diet with both cognitive and physical exercises.
In 1906, a German physician named Dr. Alois Alzheimer dealt with a patient that had been battling severe memory and confusion problems and had tremendous difficulty understanding questions and basic functions. Alzheimer suspected that the ailment had more to it than inherent memory loss. During an autopsy of the brain, he discovered that there were deposits of neuritic plaques surrounding the nerve cells and twisted fibers, known as neurofibrillary tangles, inside of the nerve cells. These observations became the definitive diagnosis of Alzheimer’s disease. The plaques and tangles that develop are a natural part of aging; however, they develop far more aggressively in Alzheimer’s victims. The plaques and tangles then block communication among nerve cells and disrupt the cells processes, eventually killing them. This destruction causes memory failure, personality changes, and problems carrying out everyday functions. Alzheimer’s especially attacks the memory. A victim in the later stage of the disease can...
Alzheimer’s disease or AD is an incurable disorder of the brain that results in loss of normal brain structure and function. In an AD brain, normal brain tissue is slowly replaced by structures called plaques and neurofibrillary tangles. The plaques represent a naturally occurring sticky protein called beta amyloid and in an Alzheimer’s brain, sufferer’s tend to accumulate too much of this protein. Neurofibrillary tangles represent collapsed tau proteins which, in a normal brain along with microtubules, form a skeleton that maintains the shape of the nerve cells. In Alzheimer’s disease, the tau proteins break loose from their normal location and form tangles. Without the support of these molecules, nerve cells collapse and die. As normal brain structure is lost with progression of the disease, brain function also degenerates. Patients afflicted with Alzheimer’s disease display a gradual mental decline. Initially, and most apparently, there is a loss of short-term memory. Eventually, as a patient progresses to later stages of the disease, the brain becomes so damaged that patients can no longer communicate or recognize immediate family or even themselves. They have difficulty walking and standing and frequently fall. In the final stages, they lose bladder and bowel control and have difficulty with swallowing, frequently leaving them malnourished and dehydrated. Eventually, they are forced to remain bedridden and, without the help of life-prolonging measures provided in a hospital, die. However, this level of deterioration is severe and may take as long as twenty years. Because of the disease’s slow progress and its usual later start in a person’s life, a victim of AD will usually die first of natural causes. Under the objectives ...
Although there is no treatment can stop Alzheimer’s disease. However, some drugs such as rivastigmine may help to keep the symptoms from getting worse for a limited time. (MedicinePlus, 2014) Today, Alzheimer's is at the forefront of biomedical research. Researchers are working to uncover as many aspects of Alzheimer's disease Ninety percent of what people know about Alzheimer's has been discovered in the last 15 years. Some of the most remarkable progress is how Alzheimer's affects the brain. The hope is this well understanding will lead to new treatments. Many potential approaches are currently under investigation worldwide. (Alzheimer’s Association, 2014)
The elderly represents a large amount of the population in our society and continues to grow each day. As the population grows, it is important to meet the demands and resolve the challenges that we encounter in regards to the overall quality of health and well-being of the elderly. Mental health of the elderly is a major issue but majority of the time goes unnoticed and untreated by caregivers and loved ones. About 20 percent of adults 55 and older are suffering from some type of mental health disorder, and one in three elderly adults do not receive any type of treatment (The State of Mental Health, 2008). Those suffering from mental illness are hesitant to seek out help or any type of treatment because of the stigma, services and cost for care that then comes with mental health disorders. Mental health issues that affect elderly include dementia, delirium, and psychosis. Some of the most common conditions include anxiety, mood disorders such as depression and bipolar disorder and cognitive impairment such as Alzheimer’s disease. Mental health is essential to the
Alzheimer’s Disease is named after a German doctor, who specializes in the brain and nervous system, named Alois Alzheimer. This Disease forms in the brain. Alzheimer’s is the most common form of Dementia, a general term for memory loss and other intellectual abilities serious enough to enter. The Tau protein ensures the tubes in your brain stay straight allowing molecules to pass through freely. In Alzheimer’s Disease the protein collapses into strands or tangles, making the tubes disintegrate. There is visible differences of brain tissue in the from misfolded proteins called plaques and tangles. Beta-Amyloid clumps block signals and communication between cells in the brain. Researchers agree that Alzheimer’s Disease is m...