The Adverse Effects of Exposure to Benzene

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1. INTRODUCTION

Benzene (also known as benzol) is a colourless and highly flammable liquid with a sweet odour. It evaporates into the air very quickly and partly dissolves in water. Most people can begin to smell benzene in air at approximately 60 ppm of air and recognize it as benzene at 100 ppm. It was first discovered and extracted from coal tar in the 1980s and subsequently from petroleum due to vast increase in its demand. Since then, various industries use benzene to make other chemicals, such as styrene, cumene and cyclohexane. Benzene is also an important ingredient for the manufacturing of some types of rubbers, lubricants, dyes, detergents, drugs and pesticide. Hence, individuals employed in these industries may be exposed to benzene in air far greater than the levels normally encountered by the general population. [1]

Concerns on potential health effects resulting from benzene exposure such as bone marrow depression leading to anaemia, leukopenia and thrombocytopenia, as well as decreases in circulating blood cells have been reported. In addition, laboratory studies on humans and animals indicated that benzene exerts its effect by damaging the genetic material of cells. Hence, benzene is being classified as confirmed human carcinogen. [2]

In Singapore, every employer has the responsibility to take reasonably practicable steps in ensuring no one at work is exposed to benzene above the permissible exposure level (PEL) specified in regulations. The prescribed permissible exposure limit (long term) for benzene is 1 ppm over an 8-hour working day and a 40-hour workweek. [3] These exposure standards are usually set based on risk evaluation using data obtained from human and/or animal health effects studies. [4]

Thus, this...

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... [8] Animal and human studies provide clear evidence of a causal relationship between occupational exposure to benzene that lead to aplastic anemia.

Lan et al. [7] reported that bone marrow toxicity was detected from a group of workers after several months of exposure to benzene in air level at or below 1 ppm. Hence, local PEL setting should be amended to TLV-TWA of 0.5 ppm recommended by ACGIH to minimise the potential of adverse health effects posed by occupational exposure.

Alternatively, the whole world should adopt a single internationally agreed system such as Globally Harmonised System (GHS) under the auspices of United Nations. GHS enables country to adopt a single and unilateral system, reduce duplicative testing and evaluation of chemical, facilitate trade in chemicals where hazards can be properly assessed and identified on an international basis. [15]

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